Mouse Anti-B4GAT1 Recombinant Antibody (2H6) (CBMAB-A0690-LY)

Name: Mouse Anti-B4GAT1 Recombinant Antibody (2H6)
SKU: CBMAB-A0690-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2H6

Application

ELISA

Immunogen

B4GAT1 (NP_006867.1, 316 a.a. ~ 415 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1

Introduction

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq]

Entrez Gene ID

11041

UniProt ID

O43505

Alternative Names

B3GN-T1; B3GNT6; BETA3GNTI; iGAT; iGNT

Function

Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697).
Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697).
Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (By similarity).

Biological Process

Keratan sulfate biosynthetic process Source: Reactome
Protein O-linked glycosylation Source: Reactome
Protein O-linked mannosylation Source: UniProtKB

Cellular Location

Golgi apparatus membrane. Localizes near the trans-Golgi apparatus.

Involvement in disease

Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A13 (MDDGA13): An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye-brain disease.

Topology

Cytoplasmic: 1-8 aa
Helical: 9-36 aa
Lumenal: 37-415 aa

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-B4GAT1 Recombinant Antibody (CBYY-0101) (CAT#: CBMAB-0101-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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