Mouse Anti-BARX1 Recombinant Antibody (1E7) (CBMAB-A0713-LY)

The product is antibody recognizes BARX1. The antibody 1E7 immunoassay techniques such as: WB, ELISA.
See all BARX1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1E7

Antibody Isotype

IgG1, λ

Application

WB, ELISA

Basic Information

Immunogen

BARX1 (AAH09458, 1 a.a. ~ 100 a.a) full-length recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

BARX homeobox 1

Introduction

This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq]

Entrez Gene ID

56033

UniProt ID

Q9HBU1

Function

Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity).
Binds to a regulatory module of the NCAM promoter.

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Cell-cell signaling Source: Ensembl
Digestive system development Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spleen development Source: Ensembl

Cellular Location

Nucleus

References

Sun, G., Ge, Y., Zhang, Y., Yan, L., Wu, X., Ouyang, W., ... & Ye, Z. (2021). Transcription Factors BARX1 and DLX4 Contribute to Progression of Clear Cell Renal Cell Carcinoma via Promoting Proliferation and Epithelial–Mesenchymal Transition. Frontiers in molecular biosciences, 8, 453.

Fadista, J., Skotte, L., Geller, F., Bybjerg-Grauholm, J., Gørtz, S., Romitti, P. A., ... & Feenstra, B. (2019). Genome-wide meta-analysis identifies BARX1 and EML4-MTA3 as new loci associated with infantile hypertrophic pyloric stenosis. Human molecular genetics, 28(2), 332-340.

Lin, X., Yang, H., Wang, L., Li, W., Diao, S., Du, J., ... & Fan, Z. (2019). AP2a enhanced the osteogenic differentiation of mesenchymal stem cells by inhibiting the formation of YAP/RUNX2 complex and BARX1 transcription. Cell proliferation, 52(1), e12522.

Yan, C., Ji, Y., Huang, T., Yu, F., Gao, Y., Gu, Y., ... & Jin, G. (2018). An esophageal adenocarcinoma susceptibility locus at 9q22 also confers risk to esophageal squamous cell carcinoma by regulating the function of BARX1. Cancer letters, 421, 103-111.

Wang, G., Liu, J., Cai, Y., Chen, J., Xie, W., Kong, X., ... & Wu, K. (2017). Loss of Barx1 promotes hepatocellular carcinoma metastasis through up-regulating MGAT5 and MMP9 expression and indicates poor prognosis. Oncotarget, 8(42), 71867.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-BARX1 Recombinant Antibody (CBYY-0199)

Mouse Anti-BARX1 Recombinant Antibody (1B3)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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