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Mouse Anti-BATF2 Recombinant Antibody (2B9) (CBMAB-0154-YC)

Provided herein are mouse monoclonal antibodies against Human BATF2. The antibody clone 2B9 can be used for immunoassay techniques, such as IP and MA.
See all BATF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B9
Antibody Isotype
IgG2b, κ
Application
IP, ELISA, IHC, FC

Basic Information

Immunogen
Recombinant fragment (around aa5-140) of human MGC20410.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC1-2 µg/10^6 cells
IHC1-2 µg/ml
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.02% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BATF2
Introduction
Basic leucine zipper transcription factor, ATF-Like 2 (BATF2) is a transcription factor. Diseases associated with BATF2 include cercarial dermatitis. An important paralog of this gene is BATF.
Entrez Gene ID
116071
UniProt ID
Q8N1L9
Alternative Names
Basic Leucine Zipper Transcription Factor, ATF-Like 2; Suppressor Of AP-1 Regulated By IFN; B-ATF-2; SARI
Function
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity).
Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.
Biological Process
Defense response to protozoan Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Zhang, X., Liu, Y., Dai, L., Shi, G., Deng, J., Luo, Q., ... & Deng, H. (2021). BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells. Oncogene, 40(8), 1516-1530.

Li, C., Liu, M., Liu, K., Li, M., Liu, Y., Li, T., ... & Zhang, H. (2021). BATF2 balances the T cell-mediated immune response of CADM with an anti-MDA5 autoantibody. Biochemical and Biophysical Research Communications, 551, 155-160.

Yu, C., Li, D., Yan, Q., Wang, Y., Yang, X., Zhang, S., ... & Zhang, Z. (2021). Circ_0005927 Inhibits the Progression of Colorectal Cancer by Regulating miR-942-5p/BATF2 Axis. Cancer Management and Research, 13, 2295.

Lin, W., Miao, Y., Meng, X., Huang, Y., Zhao, W., & Ruan, J. (2020). miRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells. FEBS Open bio, 10(6), 1021-1030.

Mamoor, S. (2020). BATF2 and FOXJ1 are differentially expressed in coronavirus infections.

Yang, W., Wu, B., Ma, N., Wang, Y., Guo, J., Zhu, J., & Zhao, S. (2019). BATF2 reverses multidrug resistance of human gastric cancer cells by suppressing Wnt/β-catenin signaling. In Vitro Cellular & Developmental Biology-Animal, 55(6), 445-452.

Wang, Q., Lu, W., Yin, T., & Lu, L. (2019). Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells. Journal of Experimental & Clinical Cancer Research, 38(1), 1-12.

Kanemaru, H., Yamane, F., Tanaka, H., Maeda, K., Satoh, T., & Akira, S. (2018). BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation. International immunology, 30(6), 255-265.

Kanemaru, H., Yamane, F., Fukushima, K., Matsuki, T., Kawasaki, T., Ebina, I., ... & Akira, S. (2017). Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proceedings of the National Academy of Sciences, 114(35), E7331-E7340.

Huang, W., Zhang, C., Cui, M., Niu, J., & Ding, W. (2017). Inhibition of Bevacizumab-induced Epithelial–Mesenchymal Transition by BATF2 Overexpression Involves the Suppression of Wnt/β-Catenin Signaling in Glioblastoma Cells. Anticancer research, 37(8), 4285-4294.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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