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Mouse Anti-BCL2L13 Recombinant Antibody (CBYY-0419) (CBMAB-0421-YY)

This product is mouse antibody that recognizes BCL2L13. The antibody CBYY-0419 can be used for immunoassay techniques such as: ELISA, WB
See all BCL2L13 antibodies
Published Data
Mouse Anti-BCL2L13 Recombinant Antibody (CBYY-0419) (CBMAB-0421-YY) in WB
BCL2L13 expression is conspicuously lower in CAKi-1 cells and 786-0 cells, compared to HEK293T cells. ...View More
Meng, F., Zhang, L., Zhang, M., Ye, K., Guo, W., Liu, Y., ... & Dai, H. (2021). Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma. Cancer Cell International, 21(1), 1-12.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0419
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IF, IP

Basic Information

Immunogen
Amino acids 9-112 mapping near the N-terminus of Bcl-rambo of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2-like 13 (apoptosis facilitator)
Introduction
This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Entrez Gene ID
23786
UniProt ID
Q9BXK5
Alternative Names
BCL2 Like 13; BCL2-Like 13 (Apoptosis Facilitator); BCL-RAMBO; Bcl2-L-13; MIL1; Bcl-2-Like Protein 13; Protein Mil1;
Function
May promote the activation of caspase-3 and apoptosis.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: UniProtKB
Regulation of apoptotic process Source: InterPro
Cellular Location
Isoform 1: Nucleus
Isoform 2: Mitochondrion membrane; Nucleus
Topology
Helical: 460 -480 aa

Huang, Y., Deng, L., Zeng, L., Bao, S., Ye, K., Li, C., ... & Xiong, Z. (2021). Silencing of H19 alleviates oxygen–glucose deprivation/reoxygenation-triggered injury through the regulation of the miR-1306-5p/BCL2L13 axis. Metabolic Brain Disease, 1-12.

Meng, F., Sun, N., Liu, D., Jia, J., Xiao, J., & Dai, H. (2021). BCL2L13: Physiological and pathological meanings. Cellular and Molecular Life Sciences, 78(6), 2419-2428.

Guo, Z., Zhang, G., Xu, B., Zhang, C., Tao, A., He, M., & He, X. (2021). Circ_0062166 aggravates cerebral ischemia-reperfusion injury through targeting miR-526b-5p/BCL2L13 axis. Brain Injury, 1-9.

Meng, F., Zhang, L., Zhang, M., Ye, K., Guo, W., Liu, Y., ... & Dai, H. (2021). Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma. Cancer Cell International, 21(1), 1-12.

Lu, Y., Han, Y., He, J., Zhou, B., Fang, P., & Li, X. (2020). LncRNA FOXD3-AS1 knockdown protects against cerebral ischemia/reperfusion injury via miR-765/BCL2L13 axis. Biomedicine & Pharmacotherapy, 132, 110778.

Zhang, X., Huang, C. R., Pan, S., Pang, Y., Chen, Y. S., Zha, G. C., ... & Zheng, X. (2020). Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression. International immunopharmacology, 83, 106425.

Fujiwara, M., Tian, L., Le, P. T., DeMambro, V. E., Becker, K. A., Rosen, C. J., & Guntur, A. R. (2019). The mitophagy receptor Bcl-2–like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice. Journal of Biological Chemistry, 294(34), 12683-12694.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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