Mouse Anti-BET1L Recombinant Antibody (19) (CBMAB-G0009-LY)

This product is antibody recognizes BET1L. The antibody 19 immunoassay techniques such as: WB.
See all BET1L antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Rat, Human, Dog, Mouse

Clone

Antibody Isotype

IgG1, κ

Application

WB, IP, IF

Basic Information

Immunogen

Amino acids 1-85 of Bet1L of rat origin.

Host Species

Mouse

Specificity

Rat, Human, Dog, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Bet1 Golgi Vesicular Membrane Trafficking Protein Like

Entrez Gene ID

Human	51272
Mouse	54399
Rat	54400
Dog	483393
Frog	446471

UniProt ID

Human	Q9NYM9
Mouse	O35153
Rat	O35152
Dog	E2QW29
Frog	F6VLD5

Function

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Protein transport Source: UniProtKB-KW
Regulation of retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Retrograde transport, endosome to Golgi Source: HGNC-UCL

Cellular Location

Golgi apparatus membrane; Trans-Golgi network membrane. Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks.

Topology

Cytoplasmic: 1-86 aa
Helical: 87-107 aa
Lumenal: 108-111 aa

References

Lynch, E. M., Robertson, S., FitzGibbons, C., Reilly, M., Switalski, C., Eckardt, A., ... & Suzuki, M. (2021). Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular junction degeneration in ALS. Experimental Neurology, 345, 113815.

Chen, Y., & Sima, X. (2019). Replication of GWAS loci revealed an increased risk of BET1L and H19 polymorphisms with intracranial aneurysm. Disease markers, 2019.

Liu, B., Wang, T., Jiang, J., Li, M., Ma, W., Wu, H., & Zhou, Q. (2018). Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population. Scientific reports, 8(1), 1-6.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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