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Rabbit Anti-BGLAP Recombinant Antibody (CBYY-0530) (CBMAB-0533-YY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYY-0530
Antibody Isotype
IgG
Application
WB, IHC

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the carboxy terminus of human osteocalcin protein.
Host Species
Rabbit
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IHC1:250-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM HEPES, pH 7.5, 0.15M NaCl, 0.1mg/mL BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 220-300

Target

Full Name
Bone Gamma-Carboxyglutamate Protein
Introduction
This gene encodes a highly abundant Bovinene protein secreted by osteoblasts that regulates Bovinene remodeling and energy metaBovinelism. The encoded protein contains a Gla (gamma carBovinexyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of Bovinene. Serum osteocalcin levels may be negatively correlated with metaBovinelic syndrome. Read-through transcription exists between this gene and the neighBovinering upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Entrez Gene ID
632
UniProt ID
P02818
Alternative Names
Bovinene Gamma-CarBovinexyglutamate Protein; Gamma-CarBovinexyglutamic Acid-Containing Protein; Bovinene Gla Protein; Osteocalcin; BGP; Bovinene Gamma-CarBovinexyglutamate (Gla) Protein (Osteocalcin); Bovinene Gamma-CarBovinexyglutamate (Gla) Protein; OCN; OC;
Function
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Biological Process
Bone development Source: GO_Central
Bone mineralization Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Odontogenesis Source: Ensembl
Osteoblast development Source: Ensembl
Osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: InterPro
Regulation of bone resorption Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: InterPro
Regulation of osteoclast differentiation Source: UniProtKB
Response to activity Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to gravity Source: Ensembl
Response to hydroxyisoflavone Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin D Source: BHF-UCL
Response to vitamin K Source: Ensembl
Response to zinc ion Source: Ensembl
Skeletal system development Source: ProtInc
Cellular Location
Secreted
PTM
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
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For research use only. Not intended for any clinical use.

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