Mouse Anti-BGLAP Recombinant Antibody (6F9G4E10) (CBMAB-O0045-CQ)

Name: Mouse Anti-BGLAP Recombinant Antibody (6F9G4E10)
SKU: CBMAB-O0045-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6F9G4E10

Application

ELISA

Immunogen

Recombinant human osteocalcin protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Bone Gamma-Carboxyglutamate Protein

Introduction

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.

Entrez Gene ID

632

UniProt ID

P02818

Alternative Names

Bone Gamma-Carboxyglutamate (Gla) Protein; Gamma-Carboxyglutamic Acid-Containing Protein; BGP; Bone Gamma-Carboxyglutamate (Gla) Protein (Osteocalcin); Bone Gla Protein; Osteocalcin; OCN

Function

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Biological Process

Bone development Source: GO_Central
Bone mineralization Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Odontogenesis Source: Ensembl
Osteoblast development Source: Ensembl
Osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: InterPro
Regulation of bone resorption Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: InterPro
Regulation of osteoclast differentiation Source: UniProtKB
Response to activity Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to gravity Source: Ensembl
Response to hydroxyisoflavone Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin D Source: BHF-UCL
Response to vitamin K Source: Ensembl
Response to zinc ion Source: Ensembl
Skeletal system development Source: ProtInc

Cellular Location

Secreted

PTM

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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