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Mouse Anti-BGLAP Recombinant Antibody (C8) (CBMAB-O0150-CQ)


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Summary

Host Animal
Mouse
Specificity
Cattle, Human
Clone
C8
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Amino acids 1-100 representing full length osteocalcin of human origin.
Host Species
Mouse
Specificity
Cattle, Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Gamma-Carboxyglutamate Protein
Introduction
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
Entrez Gene ID
Human632
Cattle281646
UniProt ID
HumanP02818
CattleP02820
Alternative Names
Bone Gamma-Carboxyglutamate (Gla) Protein; Gamma-Carboxyglutamic Acid-Containing Protein; BGP; Bone Gamma-Carboxyglutamate (Gla) Protein (Osteocalcin); Bone Gla Protein; Osteocalcin; OCN
Function
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Biological Process
Bone development Source: GO_Central
Bone mineralization Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Odontogenesis Source: Ensembl
Osteoblast development Source: Ensembl
Osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: InterPro
Regulation of bone resorption Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: InterPro
Regulation of osteoclast differentiation Source: UniProtKB
Response to activity Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to gravity Source: Ensembl
Response to hydroxyisoflavone Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin D Source: BHF-UCL
Response to vitamin K Source: Ensembl
Response to zinc ion Source: Ensembl
Skeletal system development Source: ProtInc
Cellular Location
Secreted
PTM
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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