BGLAP

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
Full Name
Bone Gamma-Carboxyglutamate Protein
Function
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Biological Process
Bone development Source: GO_Central
Bone mineralization Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Odontogenesis Source: Ensembl
Osteoblast development Source: Ensembl
Osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: InterPro
Regulation of bone resorption Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: InterPro
Regulation of osteoclast differentiation Source: UniProtKB
Response to activity Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to gravity Source: Ensembl
Response to hydroxyisoflavone Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin D Source: BHF-UCL
Response to vitamin K Source: Ensembl
Response to zinc ion Source: Ensembl
Skeletal system development Source: ProtInc
Cellular Location
Secreted
PTM
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
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Anti-BGLAP antibodies

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Mouse Anti-BGLAP Recombinant Antibody (2D5) (CBMAB-A0755-LY)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 2D5
Application*: WB, E
Datasheet SDS

Rabbit Anti-BGLAP Recombinant Antibody (CBYY-0530) (CBMAB-0533-YY)

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Target: BGLAP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYY-0530
Application*: WB, IH
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (3H8H12D2A12F12) (CBMAB-O0158-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human, Pig, Rabbit, Rat
Clone: 3H8H12D2A12F12
Application*: E
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (E6) (CBMAB-O0156-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: E6
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (C8) (CBMAB-O0150-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Cattle, Human
Clone: C8
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (2D4) (CBMAB-O0147-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 2D4
Application*: E, WB
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (G5) (CBMAB-O0091-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: G5
Application*: E, IF, IH, WB, P
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (6F9G4E10) (CBMAB-O0045-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F9G4E10
Application*: E
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (2H9F11F8) (CBMAB-O0034-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Pig, Cattle, Rabbit
Clone: 2H9F11F8
Application*: E
Datasheet SDS

Mouse Anti-BGLAP Recombinant Antibody (8H12F9H10) (CBMAB-O0019-CQ)

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Target: BGLAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Pig, Rabbit, Rat
Clone: 8H12F9H10
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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