BGLAP

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.

Bone Gamma-Carboxyglutamate Protein

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Bone development Source: GO_Central
Bone mineralization Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell aging Source: Ensembl
Cellular response to growth factor stimulus Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Odontogenesis Source: Ensembl
Osteoblast development Source: Ensembl
Osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: InterPro
Regulation of bone resorption Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: InterPro
Regulation of osteoclast differentiation Source: UniProtKB
Response to activity Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to gravity Source: Ensembl
Response to hydroxyisoflavone Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to testosterone Source: Ensembl
Response to vitamin D Source: BHF-UCL
Response to vitamin K Source: Ensembl
Response to zinc ion Source: Ensembl
Skeletal system development Source: ProtInc

Secreted

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.