Mouse Anti-BHLHE40 Recombinant Antibody (5B1) (CBMAB-A0759-LY)

basic helix-loop-helix family, member e40

This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation. [provided by RefSeq]

BHLHB2; DEC1; FLJ99214; SHARP-2; STRA13; Stra14

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297).
Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706).
Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144).
Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782).
Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706).
Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558).
May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558).
Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-ARNTL/BMAL1 complex (PubMed:28797635).
Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868).

Anterior/posterior pattern specification Source: GO_Central
Circadian regulation of gene expression Source: BHF-UCL
Circadian rhythm Source: UniProtKB
Entrainment of circadian clock by photoperiod Source: BHF-UCL
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of neurogenesis Source: GO_Central
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus; Cytoplasm. Predominantly localized in the nucleus (PubMed:11278694).

Ubiquitinated; which may lead to proteasomal degradation.
Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-ARNTL/BMAL1 heterodimer transcriptional activator activity.