Mouse Anti-BLK Recombinant Antibody (CBT2139) (V2LY-0625-LY2141)
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Basic Information
| Application | Note |
| WB | 1:500-1:2,000 |
| IHC-P | 1:200-1:1,000 |
| ELISA | 1:10,000 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity).
Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity).
Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity).
Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity).
Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631).
With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity).
Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity).
In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185).
Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214).
Cell differentiation Source: GO_Central
Cellular response to DNA damage stimulus Source: GO_Central
Dendritic cell differentiation Source: GO_Central
Fc receptor mediated stimulatory signaling pathway Source: GO_Central
Innate immune response Source: GO_Central
Intracellular signal transduction Source: ProtInc
Negative regulation of B cell proliferation Source: GO_Central
Negative regulation of mast cell proliferation Source: GO_Central
Neuron projection development Source: GO_Central
Peptidyl-tyrosine phosphorylation Source: UniProtKB
Platelet degranulation Source: GO_Central
Positive regulation of dendritic cell apoptotic process Source: GO_Central
Positive regulation of insulin secretion Source: UniProtKB
Regulation of B cell apoptotic process Source: GO_Central
Regulation of B cell receptor signaling pathway Source: GO_Central
Regulation of mast cell degranulation Source: GO_Central
Regulation of platelet aggregation Source: GO_Central
Tolerance induction to self antigen Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Antibody Pairs
BLK Matched Antibody Pair (140) (CAT#: APMAB-140LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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