Mouse Anti-BLOC1S6 Recombinant Antibody (1E2) (CBMAB-P0106-YC)

Name: Mouse Anti-BLOC1S6 Recombinant Antibody (1E2)
SKU: CBMAB-P0106-YC
Rating: 5 (1 reviews)

See all BLOC1S6 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E2

Application

FC, WB, IH

Immunogen

Full length human recombinant protein of human PLDN produced in HEK293T cell.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000
IHC	1:150
FC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Biogenesis Of Lysosomal Organelles Complex 1 Subunit 6

Introduction

BLOC1S6 may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Mutations in this gene cause symptoms associated with Hermansky-Pudlak syndrome-9. A pseudogene related to this gene is located on the X chromosome.

Entrez Gene ID

26258

UniProt ID

Q9UL45

Alternative Names

HPS9; PLDN; BLOS6; PALLID; PA

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

Biological Process

Anterograde axonal transport Source: UniProtKB
Anterograde synaptic vesicle transport Source: UniProtKB
Endosome to melanosome transport Source: UniProtKB
Intracellular transport Source: GO_Central
Melanosome organization Source: UniProtKB
Melanosome transport Source: UniProtKB
Neuron projection development Source: UniProtKB
Positive regulation of pigment cell differentiation Source: UniProtKB
Post-Golgi vesicle-mediated transport Source: Reactome
Synaptic vesicle docking Source: UniProtKB

Cellular Location

Cytoplasm; Membrane. It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270).

Involvement in disease

Hermansky-Pudlak syndrome 9 (HPS9): A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

PTM

Phosphorylated.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-BLOC1S6 Recombinant Antibody (1E2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-BLOC1S6 Recombinant Antibody (3D2) (CAT#: CBMAB-A6789-LY)

Mouse Anti-BLOC1S6 Recombinant Antibody (1H9) (CAT#: CBMAB-P0107-YC)

Mouse Anti-BLOC1S6 Recombinant Antibody (2H8) (CAT#: CBMAB-A6788-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry