Mouse Anti-BMP4 Recombinant Antibody (CBT224) (V2LY-0625-LY3690)

Mouse

Human

CBT224

IgG

WB, ELISA

Purified recombinant fragment of human BMP-4 expressed in E. Coli.

Mouse

Human

IgG

Monoclonal Antibody

Supernatant

BSA, Glycerol

Sodium azide

Batch dependent

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885).
Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:25868050, PubMed:8006002).
Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:25868050, PubMed:29212066).
Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades (PubMed:31363885).
For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (PubMed:31363885).

Activation of MAPKK activity Source: UniProtKB
Anterior/posterior axis specification Source: Ensembl
Aortic valve morphogenesis Source: BHF-UCL
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
BMP signaling pathway Source: BHF-UCL
BMP signaling pathway involved in heart development Source: BHF-UCL
BMP signaling pathway involved in heart induction Source: BHF-UCL
BMP signaling pathway involved in nephric duct formation Source: UniProtKB
BMP signaling pathway involved in renal system segmentation Source: UniProtKB
BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
Branching involved in prostate gland morphogenesis Source: Ensembl
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Branching morphogenesis of an epithelial tube Source: UniProtKB
Bronchus development Source: MGI
Bud dilation involved in lung branching Source: MGI
Bud elongation involved in lung branching Source: Ensembl
Cardiac muscle cell differentiation Source: Ensembl
Cardiac septum development Source: BHF-UCL
Cellular protein metabolic process Source: Reactome
Cellular response to BMP stimulus Source: BHF-UCL
Chondrocyte differentiation Source: UniProtKB
Cloacal septation Source: Ensembl
Common-partner SMAD protein phosphorylation Source: UniProtKB
Coronary vasculature development Source: BHF-UCL
Cranial suture morphogenesis Source: Ensembl
Deltoid tuberosity development Source: UniProtKB
Dorsal/ventral neural tube patterning Source: Ensembl
Embryonic cranial skeleton morphogenesis Source: Ensembl
Embryonic digit morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Embryonic skeletal joint morphogenesis Source: Ensembl
Endocardial cushion development Source: BHF-UCL
Endochondral ossification Source: UniProtKB
Endoderm development Source: Ensembl
Epithelial cell proliferation involved in lung morphogenesis Source: MGI
Epithelial-mesenchymal cell signaling Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: MGI
Erythrocyte differentiation Source: Ensembl
Germ cell development Source: Ensembl
Glomerular capillary formation Source: UniProtKB
Glomerular visceral epithelial cell development Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Inner ear receptor cell differentiation Source: Ensembl
Intermediate mesodermal cell differentiation Source: UniProtKB
Kidney development Source: UniProtKB
Lens induction in camera-type eye Source: Ensembl
Lung alveolus development Source: MGI
Lung morphogenesis Source: MGI
Lymphoid progenitor cell differentiation Source: BHF-UCL
Macrophage differentiation Source: DFLAT
Mammary gland formation Source: Ensembl
Membranous septum morphogenesis Source: BHF-UCL
Mesenchymal cell differentiation involved in kidney development Source: Ensembl
Mesenchymal cell proliferation involved in ureter development Source: Ensembl
Mesenchymal cell proliferation involved in ureteric bud development Source: Ensembl
Mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
Mesodermal cell fate determination Source: Ensembl
Mesonephros development Source: UniProtKB
Metanephric collecting duct development Source: UniProtKB
Monocyte differentiation Source: DFLAT
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
Negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
Negative regulation of cell cycle Source: HGNC-UCL
Negative regulation of cell death Source: UniProtKB
Negative regulation of cell population proliferation Source: MGI
Negative regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
Negative regulation of chondrocyte differentiation Source: Ensembl
Negative regulation of epithelial cell proliferation Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
Negative regulation of glomerulus development Source: UniProtKB
Negative regulation of immature T cell proliferation in thymus Source: BHF-UCL
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
Negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
Negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
Negative regulation of mitotic nuclear division Source: UniProtKB
Negative regulation of myoblast differentiation Source: MGI
Negative regulation of phosphorylation Source: UniProtKB
Negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of prostatic bud formation Source: Ensembl
Negative regulation of striated muscle tissue development Source: MGI
Negative regulation of T cell differentiation in thymus Source: BHF-UCL
Negative regulation of thymocyte apoptotic process Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Neural tube closure Source: Ensembl
Neuron fate commitment Source: Ensembl
Odontogenesis Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Osteoblast differentiation Source: BHF-UCL
Outflow tract septum morphogenesis Source: BHF-UCL
Pharyngeal arch artery morphogenesis Source: BHF-UCL
Pituitary gland development Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of BMP signaling pathway Source: UniProtKB
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of branching involved in lung morphogenesis Source: UniProtKB
Positive regulation of cardiac muscle fiber development Source: BHF-UCL
Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
Positive regulation of cartilage development Source: MGI
Positive regulation of cell death Source: MGI
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cell proliferation involved in outflow tract morphogenesis Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: BHF-UCL
Positive regulation of endothelial cell differentiation Source: Ensembl
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of epidermal cell differentiation Source: UniProtKB
Positive regulation of epithelial cell proliferation Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of kidney development Source: UniProtKB
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of ossification Source: MGI
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
Positive regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Positive regulation of protein binding Source: MGI
Positive regulation of protein phosphorylation Source: MGI
Positive regulation of SMAD protein signal transduction Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Post-embryonic development Source: MGI
Post-translational protein modification Source: Reactome
Protein localization to nucleus Source: UniProtKB
Pulmonary artery endothelial tube morphogenesis Source: UniProtKB
Pulmonary valve morphogenesis Source: BHF-UCL
Regulation of branching involved in prostate gland morphogenesis Source: Ensembl
Regulation of cell fate commitment Source: UniProtKB
Regulation of odontogenesis of dentin-containing tooth Source: Ensembl
Regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Regulation of protein import into nucleus Source: MGI
Regulation of smooth muscle cell differentiation Source: Ensembl
Renal system process Source: Ensembl
Secondary heart field specification Source: BHF-UCL
Sinoatrial node development Source: BHF-UCL
SMAD protein signal transduction Source: UniProtKB
Smooth muscle tissue development Source: UniProtKB
Specification of animal organ position Source: Ensembl
Specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
Steroid hormone mediated signaling pathway Source: UniProtKB
Telencephalon development Source: MGI
Telencephalon regionalization Source: Ensembl
Tendon cell differentiation Source: UniProtKB
Trachea development Source: MGI
Trachea formation Source: Ensembl
Type B pancreatic cell development Source: BHF-UCL
Ureter epithelial cell differentiation Source: UniProtKB
Ureteric bud development Source: MGI
Ureter smooth muscle cell differentiation Source: UniProtKB

Extracellular matrix

Microphthalmia, syndromic, 6 (MCOPS6): A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
Non-syndromic orofacial cleft 11 (OFC11): A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.