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Mouse Anti-BMP8A/B Recombinant Antibody (CBYY-0681) (CBMAB-0684-YY)

This product is mouse antibody that recognizes BMP8b. The antibody CBYY-0681 can be used for immunoassay techniques such as: WB, ELISA
See all BMP8A/B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0681
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 265-287 at the N-terminus of BMP-8B of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Morphogenetic Protein 8b
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.
Entrez Gene ID
656
UniProt ID
P34820
Alternative Names
Bovinene Morphogenetic Protein 8b; Osteogenic Protein 2; Bovinene Morphogenetic Protein 8 (Osteogenic Protein 2); BMP8; BMP-8B; BMP-8; OP-2; OP2;
Function
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).
Biological Process
BMP signaling pathway Source: GO_Central
Cartilage development Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Ossification Source: UniProtKB-KW
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
Skeletal system development Source: ProtInc
SMAD protein signal transduction Source: GO_Central
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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