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Recombinant Mouse Anti-BOP1 Recombinant Antibody (T7-P1B7) (CBMAB-XB0102-YC)

Provided herein is a Mouse Recombinant Antibody against Block Of Proliferation 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all BOP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
T7-P1B7
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Peptide sequence-KGHVLTRDLG
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Block Of Proliferation 1
Introduction
BOS2 (Branchiootic Syndrome 2) is a Genetic Locus. Diseases associated with BOS2 include Branchiootic Syndrome 2 and Branchiootic Syndrome.
Entrez Gene ID
23246
UniProt ID
Q14137
Alternative Names
Block Of Proliferation 1; Block Of Proliferation 1 Protein; KIAA0124;
Function
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Biological Process
Cell population proliferation Source: Ensembl
Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
Regulation of cell cycle Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: UniProtKB
Ribosomal large subunit assembly Source: UniProtKB
Ribosome biogenesis Source: UniProtKB
rRNA processing Source: Reactome
Cellular Location
Nucleolus; Nucleoplasm

Vellky, J. E., Ricke, E. A., Huang, W., & Ricke, W. A. (2021). Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. The American Journal of Pathology, 191(1), 168-179.

Yang, Y. P., Qin, R. H., Zhao, J. J., & Qin, X. Y. (2021). BOP1 silencing suppresses gastric cancer proliferation through p53 modulation. Current medical science, 41(2), 287-296.

Jia, F., Wu, Q., Wang, Z., Zhang, M., Yuan, S., Che, Y., ... & Hu, X. (2021). BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. Oxidative medicine and cellular longevity, 2021.

Li, S., Wu, H., Huang, X., Jian, Y., Kong, L., Xu, H., ... & Wang, X. (2021). BOP1 confers chemoresistance of triple‐negative breast cancer by promoting CBP‐mediated β‐catenin acetylation. The Journal of Pathology.

Li, W., Song, P., Zhao, M., Gao, L., Xie, J., & You, C. (2021). BOP1 Used as a Novel Prognostic Marker and Correlated with Tumor Microenvironment in Pan-Cancer. Journal of Oncology, 2021.

Chen, B., Dragomir, M. P., Fabris, L., Bayraktar, R., Knutsen, E., Liu, X., ... & Calin, G. A. (2020). The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling. Gastroenterology, 159(6), 2146-2162.

Gupta, R., Bugide, S., Wang, B., Green, M. R., Johnson, D. B., & Wajapeyee, N. (2019). Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway. Proceedings of the National Academy of Sciences, 116(10), 4583-4591.

Borah, N., Nukala, K. M., Vadlapudi, V., Gubbala, S. P., & Amanchy, R. (2019). BOP1–a key player of ribosomal biogenesis. Current Science, 117(3), 422.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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