Mouse Anti-BORCS5 Recombinant Antibody (1E1) (CBMAB-L0276-YJ)

Name: Mouse Anti-BORCS5 Recombinant Antibody (1E1)
SKU: CBMAB-L0276-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E1

Application

IF, WB

Immunogen

Full length human recombinant protein of human LOH12CR1 produced in HEK293T cell.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	1:4,000
WB	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BLOC-1 Related Complex Subunit 5

Introduction

As part of the BORC complex, BORCS5 may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, BORCS5 may indirectly function in cell spreading and motility.

Entrez Gene ID

118426

UniProt ID

Q969J3

Alternative Names

BLOC-1 Related Complex Subunit 5; Myrlysin; Loss Of Heterozygosity; 12; Chromosomal Region 1; Myristoylated Lysosomal Protein; LOH12CR1; Loss Of Heterozygosity 12 Chromosomal Region 1 Protein; Loss Of Heterozygosity 12 Chromosomal Region 1; BLOC-1-Related Complex Subunit 5; LOH1CR12

Function

As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility.

Biological Process

Lysosome localization Source: UniProtKB
Organelle transport along microtubule Source: UniProtKB
Positive regulation of anterograde synaptic vesicle transport Source: GO_Central

Cellular Location

Lysosome membrane

PTM

Myristoylation at Gly-2 mediates attachment to lysosome membranes.

Dupain, C., Gracia, C., Harttrampf, A. C., Rivière, J., Geoerger, B., & Massaad-Massade, L. (2019). Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at relapse is a driver of tumor progression. Oncogene, 38(47), 7200-7215.

Hartwig, C., Monis, W. J., Chen, X., Dickman, D. K., Pazour, G. J., & Faundez, V. (2018). Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC‐1 and BORC complexes. Developmental neurobiology, 78(3), 311-330.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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