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Rabbit Anti-BRD7 Recombinant Antibody (D9K2T) (CBMAB-CP3075-LY)

The product is antibody recognizes BRD7. The antibody D9K2T immunoassay techniques such as: CIP,CIP-seq.
See all BRD7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D9K2T
Antibody Isotype
IgG
Application
CIP, CIP-seq

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human BRD7 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bromodomain Containing 7
Introduction
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Entrez Gene ID
29117
UniProt ID
Q9NPI1
Alternative Names
Bromodomain Containing 7; 75 KDa Bromodomain Protein; Protein CELTIX-1; CELTIX1; BP75; Bromodomain-Containing Protein 7; Bromodomain-Containing 7; NAG4;
Function
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity).
Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
Biological Process
Cell cycle Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of histone acetylation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of signal transduction by p53 class mediator Source: Reactome
Regulation of transcription by RNA polymerase II Source: MGI
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Isoform 2: Nucleus

Li, S., Huang, Z., Zhu, Y., Yan, J., Li, J., Chen, J., ... & Ye, W. (2021). Bromodomain-containing protein 7 regulates matrix metabolism and apoptosis in human nucleus pulposus cells through the BRD7-PI3K-YAP1 signaling axis. Experimental Cell Research, 112658.

He, T., Liu, M., Tao, D., Leng, X., Wang, Z., Xie, S., ... & Yang, Y. (2021). Is BRD7 associated with spermatogenesis impairment and male infertility in humans? A case-control study in a Han Chinese population. Basic and clinical andrology, 31(1), 1-10.

Clegg, M. A., Bamborough, P., Chung, C. W., Craggs, P. D., Gordon, L., Grandi, P., ... & Humphreys, P. G. (2020). Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Journal of medicinal chemistry, 63(11), 5816-5840.

Karim, R. M., Chan, A., Zhu, J. Y., & Schönbrunn, E. (2020). Structural basis of inhibitor selectivity in the BRD7/9 subfamily of bromodomains. Journal of medicinal chemistry, 63(6), 3227-3237.

Wang, H., & Xie, Y. (2020). BRD7-mediated miR-3148 inhibits progression of cervical cancer by targeting Wnt3a/β-catenin pathway. Reproductive Sciences, 27(3), 877-887.

Vivenza, D., Garrone, O., Brizio, R., Mantovani, F., Del Sal, G., Merlano, M., ... & Lo Nigro, C. (2020). Expression and subcellular localization of the bromodomain-containing protein 7 is a prognostic biomarker in breast cancer. Anti-cancer drugs, 31(4), 423-430.

Ma, J., Niu, W., Wang, X., Zhou, Y., Wang, H., Liu, F., ... & Zhou, M. (2019). Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein. Oncology reports, 41(3), 1487-1496.

Liang, Y., Dong, B., Shen, J., Ma, C., & Ma, Z. (2019). Clinical significance of bromodomain‑containing protein 7 and its association with tumor progression in prostate cancer. Oncology letters, 17(1), 849-856.

Liu, T., Zhao, M., Liu, J., He, Z., Zhang, Y., You, H., ... & Feng, X. H. (2017). Tumor suppressor bromodomain-containing protein 7 cooperates with Smads to promote transforming growth factor-β responses. Oncogene, 36(3), 362-372.

van Beijnum, J. R., Nowak-Sliwinska, P., van Berkel, M., Wong, T. J., & Griffioen, A. W. (2017). A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7). Angiogenesis, 20(4), 641-654.

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For research use only. Not intended for any clinical use.

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