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Mouse Anti-BRD9 Antibody (1H8) (CBMAB-0174-YC)

Provided herein are mouse monoclonal antibodies against Human BRD9. The antibody clone 1H8 can be used for immunoassay techniques, such as IP, WB and MA.
See all BRD9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H8
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BRD9
Introduction
Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes. BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes.
Entrez Gene ID
65980
UniProt ID
Q9H8M2
Alternative Names
PRO9856; LAVS3040
Function
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797).
Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797).
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312).
Biological Process
Chromatin organization Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleoplasm; Nucleus; SWI/SNF complex

Wang, L., Oh, T. G., Magida, J., Estepa, G., Obayomi, S. B., Chong, L. W., ... & Evans, R. M. (2021). Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proceedings of the National Academy of Sciences, 118(35).

Fang, D., Wang, M. R., Guan, J. L., Han, Y. Y., Sheng, J. Q., Tian, D. A., & Li, P. Y. (2021). Bromodomain-containing protein 9 promotes hepatocellular carcinoma progression via activating the Wnt/β-catenin signaling pathway. Experimental Cell Research, 406(2), 112727.

Zhou, Q., Huang, J., Zhang, C., Zhao, F., Kim, W., Tu, X., ... & Yuan, J. (2020). The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair. Nature communications, 11(1), 1-13.

Dou, C., Sun, L., Wang, L., Cheng, J., Wu, W., Zhang, C., ... & Liu, J. (2020). Bromodomain-containing protein 9 promotes the growth and metastasis of human hepatocellular carcinoma by activating the TUFT1/AKT pathway. Cell death & disease, 11(9), 1-15.

Clegg, M. A., Bamborough, P., Chung, C. W., Craggs, P. D., Gordon, L., Grandi, P., ... & Humphreys, P. G. (2020). Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. Journal of medicinal chemistry, 63(11), 5816-5840.

Wang, Y., Wang, L. F., Zhang, L. L., Sun, H. B., & Zhao, J. (2020). Molecular mechanism of inhibitor bindings to bromodomain-containing protein 9 explored based on molecular dynamics simulations and calculations of binding free energies. SAR and QSAR in Environmental Research, 31(2), 149-170.

Karim, R. M., Chan, A., Zhu, J. Y., & Schönbrunn, E. (2020). Structural basis of inhibitor selectivity in the BRD7/9 subfamily of bromodomains. Journal of medicinal chemistry, 63(6), 3227-3237.

Bell, C. M., Raffeiner, P., Hart, J. R., & Vogt, P. K. (2019). PIK3CA cooperates with KRAS to promote MYC activity and tumorigenesis via the bromodomain protein BRD9. Cancers, 11(11), 1634.

Crawford, T. D., Vartanian, S., Côté, A., Bellon, S., Duplessis, M., Flynn, E. M., ... & Stokoe, D. (2017). Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorganic & medicinal chemistry letters, 27(15), 3534-3541.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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