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Mouse Anti-BRDT Recombinant Antibody (CBYY-0809) (CBMAB-0812-YY)

This product is mouse antibody that recognizes BRDT. The antibody CBYY-0809 can be used for immunoassay techniques such as: WB, IP, IF, ELISA
See all BRDT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0809
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BRDT
Introduction
BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforMouse have been found for this gene.
Entrez Gene ID
676
UniProt ID
Q58F21
Alternative Names
Bromodomain Testis Associated; Cancer/Testis Antigen 9; Bromodomain, Testis-Specific; RING3-Like Protein; CT9; Bromodomain Testis-Specific Protein; SPGF21; BRD6;
Function
Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802).
Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802).
In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802).
Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity).
Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity).
Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.
Biological Process
Cell differentiation Source: UniProtKB-KW
Chromatin remodeling Source: UniProtKB
Histone displacement Source: UniProtKB
Male meiosis I Source: UniProtKB
Male meiotic nuclear division Source: UniProtKB
mRNA processing Source: UniProtKB-KW
Positive regulation of transcription involved in meiotic cell cycle Source: UniProtKB
Regulation of RNA splicing Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
RNA splicing Source: UniProtKB-KW
Spermatogenesis Source: UniProtKB
Cellular Location
Nucleus.Detected on chromatin.
Involvement in disease
Spermatogenic failure 21 (SPGF21): An infertility disorder caused by spermatogenesis defects and characterized by acephalic spermatozoa in the semen of affected individuals. SPGF21 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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