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Mouse Anti-BRIX1 Recombinant Antibody (CBYY-1949) (CBMAB-2298-YY)


See all BRIX1 antibodies
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Published Data
CBMAB-2298-YY-1
CBMAB-2298-YY in IHC
Expression of BXDC2 in non-neoplastic urothelium (original magnification: ×200), non-invasive urothelial tumor (original magnification: ×400), and invasive urothelial tumor (original magnification: ×200). ...View More
Jiang, G., Teramoto, Y., Goto, T., Mizushima, T., Inoue, S., Ide, H., ... & Miyamoto, H. (2021). Identification of BXDC2 as a key downstream effector of the androgen receptor in modulating cisplatin sensitivity in bladder cancer. Cancers, 13(5), 975.
CBMAB-2298-YY-2
CBMAB-2298-YY in WB
Expression of potential BXDC2 upstream and downstream proteins in bladder cancer cells. (A) Western blotting of p-ATF2, p-ERK, and BXDC2 in UMUC3 cultured with ethanol (mock), SCH 772984 ("Inh"; 4 nM for 6 h), or C6 ceramide ("Act"; 10 µM for 24 h). (B) Western blotting of p-ERK, PTEN, and cleaved caspase-3 in 5637-AR, 5637-control-shRNA, and 5637-BXDC2-shRNA sublines. GAPDH served as a loading control. ...View More
Jiang, G., Teramoto, Y., Goto, T., Mizushima, T., Inoue, S., Ide, H., ... & Miyamoto, H. (2021). Identification of BXDC2 as a key downstream effector of the androgen receptor in modulating cisplatin sensitivity in bladder cancer. Cancers, 13(5), 975.
CBMAB-2298-YY-3
CBMAB-2298-YY in WB
Western blotting of BXDC2 in 647V-control vs. 647V-CDDP-resistant (R) sublines. ...View More
Jiang, G., Teramoto, Y., Goto, T., Mizushima, T., Inoue, S., Ide, H., ... & Miyamoto, H. (2021). Identification of BXDC2 as a key downstream effector of the androgen receptor in modulating cisplatin sensitivity in bladder cancer. Cancers, 13(5), 975.
CBMAB-2298-YY-4
CBMAB-2298-YY in WB
Western blotting of AR and BXDC2 in 5637, 647V, UMUC3, and TCCSUP. ...View More
Jiang, G., Teramoto, Y., Goto, T., Mizushima, T., Inoue, S., Ide, H., ... & Miyamoto, H. (2021). Identification of BXDC2 as a key downstream effector of the androgen receptor in modulating cisplatin sensitivity in bladder cancer. Cancers, 13(5), 975.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-1949
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, E, P

Basic Information

Immunogen
Amino acids 299-332 near the C-terminus of BXDC2 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BRX1, Biogenesis Of Ribosomes
Introduction
Required for biogenesis of the 60S ribosomal subunit.
Entrez Gene ID
Human55299
Mouse67832
UniProt ID
HumanQ8TDN6
MouseQ9DCA5
Alternative Names
BRX1, Biogenesis Of Ribosomes; Brix Domain-Containing Protein 2; Brix Domain Containing 2; BXDC2; BRIX; BRX1, Biogenesis Of Ribosomes, Homolog (S. Cerevisiae); Ribosome Biogenesis Protein BRX1 Homolog; BRX1, Biogenesis Of Ribosomes, Homolog;
Function
Required for biogenesis of the 60S ribosomal subunit.
Biological Process
Ribosomal large subunit assembly Source: GO_Central
rRNA processing Source: InterPro
Cellular Location
Nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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