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Rabbit Anti-BRS3 Recombinant Antibody (EG417) (CBMAB-EN475-LY)

The product is antibody recognizes BRS3 . The antibody EG417 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000.
See all BRS3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG417
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human BRS3.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bombesin Receptor Subtype 3
Introduction
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
Entrez Gene ID
680
UniProt ID
P32247
Alternative Names
Bombesin Receptor Subtype 3; Bombesin Like Receptor 3; BRS-3; Bombesin Receptor Subtype-3; G-Protein Coupled Receptor; BB3R; BB3;
Function
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Biological Process
Adult feeding behavior Source: ProtInc
Glucose metabolic process Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Regulation of blood pressure Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-41 aa
Helical: 42-63 aa
Cytoplasmic: 64-82 aa
Helical: 83-103 aa
Extracellular: 104-121 aa
Helical: 122-143 aa
Cytoplasmic: 144-163 aa
Helical: 164-184 aa
Extracellular: 185-220 aa
Helical: 221-241 aa
Cytoplasmic: 242-272 aa
Helical: 273-293 aa
Extracellular: 294-313 aa
Helical: 314-333 aa
Cytoplasmic: 334-399 aa

Dong, L., Zhang, B., Wu, L., Shang, Z., Liu, S., Jiang, X., ... & Xiao, H. (2020). Proteomics analysis of cellular BRS3 receptor activation reveals potential mechanism for signal transduction and cell proliferation. Journal of proteome research, 19(4), 1513-1521.

Li, M., Liang, P., Liu, D., Yuan, F., Chen, G. C., Zhang, L., ... & Liu, H. (2019). Bombesin Receptor Subtype-3 in Human Diseases. Archives of medical research, 50(7), 463-467.

Zhang, Y., Liu, Y., Wu, L., Fan, C., Wang, Z., Zhang, X., ... & Civelli, O. (2018). Receptor‐specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3. The FASEB Journal, 32(6), 3184-3192.

Liu, H., Peng, L., Liu, C., Tan, Y., Xiang, Y., Qu, X., ... & Qin, X. (2018). Activation of bombesin receptor subtype-3 promotes antigen-presenting action in human bronchial epithelial cells. International archives of allergy and immunology, 175(1-2), 53-60.

Moreno, P., Mantey, S. A., Lee, S. H., Ramos-Álvarez, I., Moody, T. W., & Jensen, R. T. (2018). A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3. Peptides, 101, 213-226.

Moreno-Villegas, Z., Martín-Duce, A., Aparicio, C., Portal-Núñez, S., Sanz, R., Mantey, S. A., ... & González, N. (2018). Activation of bombesin receptor Subtype-3 by [D-Tyr6, β-Ala11, Phe13, Nle14] bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes. Molecular and cellular endocrinology, 474, 10-19.

Nio, Y., Hotta, N., Maruyama, M., Hamagami, K., Nagi, T., Funata, M., ... & Nagisa, Y. (2017). A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced–Obese Rats With Circadian Rhythm Change. Endocrinology, 158(5), 1298-1313.

Mo, C., Huang, L., Cui, L., Lv, C., Lin, D., Song, L., ... & Wang, Y. (2017). Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. Journal of molecular endocrinology, 59(1), 61-79.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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