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Mouse Anti-BTF3 Recombinant Antibody (CBYY-2132) (CBMAB-2481-YY)

This product is mouse antibody that recognizes BTF3. The antibody CBYY-2132 can be used for immunoassay techniques such as: Dot, ICC, WB, FC
See all BTF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-2132
Antibody Isotype
IgG2b
Application
Dot, ICC, WB, FC

Basic Information

Immunogen
BTF3 antibody was raised in mouse using recombinant Human Basic Transcription Factor 3
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
basic transcription factor 3
Introduction
This gene encodes the basic transcription factor 3. This protein forMouse a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforMouse. This gene has multiple pseudogenes.
Entrez Gene ID
UniProt ID
Alternative Names
Basic Transcription Factor 3; Nascent-Polypeptide-Associated Complex Beta Polypeptide; Nascent Polypeptide-Associated Complex Subunit Beta; RNA Polymerase B Transcription Factor 3; NAC-Beta; NACB;
Function
When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.
Biological Process
In utero embryonic development Source: Ensembl
Protein transport Source: UniProtKB-KW
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Cytoplasm; Nucleus. The heterodimer with NACA is cytoplasmic.

Niu, N. N., Li, Y. Q., Guo, L., Liu, Q. Y., Zhang, Y. Q., Guo, Z., ... & Wu, D. (2021). Study on the correlation between the expression of basic transcription factor 3 (BTF3) and the efficacy and prognosis of patients with malignant melanoma (MM).

Zhang, Y., Gao, X., Yi, J., Sang, X., Dai, Z., Tao, Z., ... & Liu, P. (2021). BTF3 confers oncogenic activity in prostate cancer through transcriptional upregulation of Replication Factor C. Cell death & disease, 12(1), 1-15.

Wang, H., Xing, J., Wang, W., Lv, G., He, H., Lu, Y., ... & Li, X. (2020). Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer. Frontiers in Cell and Developmental Biology, 8.

Liu, Q., Jiang, L., Wang, W., & Jiang, T. (2019). BTF3 silencing inhibits the proliferation of osteosarcoma cells. Journal of Cancer, 10(8), 1855.

Li, X., Sui, J., Xing, J., Cao, F., Wang, H., Fu, C., & Wang, H. (2019). Basic transcription factor 3 expression silencing attenuates colon cancer cell proliferation and migration in vitro. Oncology letters, 17(1), 113-118.

Liu, Q., Wu, J., Lu, T., Fang, Z., Huang, Z., Lu, S., ... & Li, M. (2019). Positive expression of basic transcription factor 3 predicts poor survival of colorectal cancer patients: possible mechanisms involved. Cell death & disease, 10(7), 1-11.

Chen, P., Zhong, Q., Li, Z., Zhang, Y., & Huang, Z. (2019). Expression and clinical significance of basic transcription factor 3 in nasopharyngeal carcinoma. Oncology letters, 17(1), 789-796.

Ding, J., Wang, X., Zhang, Y., Sang, X., Yi, J., Liu, C., ... & Cheng, H. (2019). Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα. Cancer letters, 440, 54-63.

Zhang, D. Z., Chen, B. H., Zhang, L. F., Cheng, M. K., Fang, X. J., & Wu, X. J. (2017). Basic transcription factor 3 is required for proliferation and epithelial–mesenchymal transition via regulation of FOXM1 and JAK2/STAT3 signaling in gastric cancer. Oncology research, 25(9), 1453.

Peng, X., Wang, Q., Liu, H., & Shen, S. (2017). Phylogenetic and functional analysis of the basic transcription factor gene BTF3 from Jatropha curcas. Plant Growth Regulation, 82(2), 247.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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