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Mouse Anti-AKIP1 Recombinant Antibody (V2-611696) (CBMAB-A0925-LY)

The product is antibody recognizes C11orf17. The antibody 2B11 immunoassay techniques such as: WB, ELISA.
See all AKIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611696
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
C11orf17 (NP_065693.2, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
A-Kinase Interacting Protein 1
Entrez Gene ID
56672
UniProt ID
Q9NQ31
Alternative Names
AKIP1; BCA3
Function
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Biological Process
Regulation of NIK/NF-kappaB signaling Source: InterPro
Substrate adhesion-dependent cell spreading Source: Ensembl
Cellular Location
Nucleus. Locates to punctate spots.

Sun, Y., Shi, G., Ma, C., Jiao, J., Liu, Y., Gao, Q., ... & Feng, Q. (2021). Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival. Medicine, 100(14).

Zhang, X., Liu, S., & Zhu, Y. (2020). A‐kinase‐interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer. Cell biochemistry and function, 38(6), 782-791.

Hao, X., Gu, M., Sun, J., & Cong, L. (2020). A‐kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C‐X‐C motif) ligand 1/chemokine (C‐X‐C motif) ligand 2 in acute myeloid leukemia. Journal of clinical laboratory analysis, 34(2), e23052.

Chen, H., Yan, S., Dong, L., & Li, X. (2020). A‐kinase‐interacting protein 1 overexpression correlates with deteriorative tumor features and worse survival profiles, and promotes cell proliferation but represses apoptosis in non‐small‐cell lung cancer. Journal of clinical laboratory analysis, 34(2), e23061.

Wang, D., Luo, Y., Guo, Y., Li, G., & Li, F. (2020). A-kinase interacting protein 1, a potential biomarker associated with advanced tumor features and CXCL1/2 in prostate cancer. The International journal of biological markers, 35(2), 74-81.

Fang, T., & Lu, Q. (2020). A‐kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients. Journal of clinical laboratory analysis, 34(6), e23213.

Yan, Y., Li, X., & Gao, J. (2020). Identification of A‐kinase interacting protein 1 as a potential biomarker for risk and prognosis of acute myeloid leukemia. Journal of clinical laboratory analysis, 34(5), e23055.

Zhang, L., Tao, H., Ke, K., & Ma, C. (2020). A‐kinase interacting protein 1 as a potential biomarker of advanced tumor features and increased recurrence risk in papillary thyroid carcinoma patients. Journal of clinical laboratory analysis, 34(10), e23452.

Chen, D., Cao, G., & Liu, Q. (2019). A‐kinase‐interacting protein 1 facilitates growth and metastasis of gastric cancer cells via Slug‐induced epithelial‐mesenchymal transition. Journal of cellular and molecular medicine, 23(6), 4434-4442.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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