Mouse Anti-MIEN1 Recombinant Antibody (3B5) (CBMAB-A0941-LY)

Name: Mouse Anti-MIEN1 Recombinant Antibody (3B5)
SKU: CBMAB-A0941-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3B5

Application

WB, ELISA

Immunogen

C17orf37 (NP_115715.3, 1 a.a. ~ 115 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Migration And Invasion Enhancer 1

Entrez Gene ID

84299

UniProt ID

Q9BRT3

Alternative Names

C35; MGC14832; ORB3; RDX12; XTP4

Function

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Biological Process

Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Response to selenium ion Source: GO_Central

Cellular Location

Cytosol
Plasma membrane
Cell membrane
Note: Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

PTM

Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.

Cheng, L., Shi, H., Du, L., Liu, Q., Yue, H., Zhang, H., ... & Shen, Y. (2024). Hemodynamic force dictates endothelial angiogenesis through MIEN1‐ERK/MAPK‐signaling axis. Journal of Cellular Physiology.

Zeng, C., Guo, J., Wu, J., Che, T., Huang, X., Liu, H., & Lin, Z. (2023). HRD1 promotes non-small cell lung carcinoma metastasis by blocking autophagy-mediated MIEN1 degradation. Journal of Biological Chemistry, 299(6).

Tripathi, A. K., Desai, P. P., & Vishawanatha, J. K. (2023). First Report of the Peptide Inhibitors of Cancer Cell Migration From MIEN1 Protein Sequence.

Xu, J., Qu, Q., Liu, B., & Shen, L. (2022). The circular RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1) axis promotes the progression of polycystic ovary syndrome. Bioengineered, 13(3), 5999-6011.

Liu, Y., Wang, X., Li, H., Guan, E., & Luo, K. (2021). Propofol ameliorates the proliferation and epithelial-mesenchymal transition of hepatoma carcinoma cells via non-coding RNA activated by DNA damage (NORAD)/microRNA (miR)-556-3p/migration and invasion enhancer 1 (MIEN1) axis. Journal of Environmental Pathology, Toxicology and Oncology, 40(4).

Liang, F., Zhang, H., Qiu, Y., Xu, Q., Jian, K., Jiang, L., ... & Lu, X. (2020). MiR-124-5p inhibits the progression of gastric cancer by targeting MIEN1. Technology in Cancer Research & Treatment, 19, 1533033820979199.

Yu, X., Xiao, W., Song, H., Jin, Y., Xu, J., & Liu, X. (2020). CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression. Gene, 748, 144678.

Cámara-Quílez, M., Barreiro-Alonso, A., Vizoso-Vázquez, Á., Rodríguez-Belmonte, E., Quindós-Varela, M., Lamas-Maceiras, M., & Cerdán, M. E. (2020). The HMGB1-2 ovarian cancer interactome. The role of HMGB proteins and their interacting partners MIEN1 and NOP53 in ovary cancer and drug-response. Cancers, 12(9), 2435.

Kushwaha, P. P., Gupta, S., Singh, A. K., & Kumar, S. (2019). Emerging role of migration and invasion enhancer 1 (MIEN1) in cancer progression and metastasis. Frontiers in oncology, 9, 868.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-MIEN1 Recombinant Antibody (3B5) (CAT#: CBMAB-X0050-YC)

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Isotype control

For research use only. Not intended for any clinical use.

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