Mouse Anti-CABLES1 Recombinant Antibody (EG449) (CBMAB-EN509-LY)

Name: Mouse Anti-CABLES1 Recombinant Antibody (EG449)
SKU: CBMAB-EN509-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

EG449

Application

WB, IP, IF, E, P

Immunogen

Amino acids 1-280 mapping at the N-terminus of Cables1 of mouse origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cdk5 And Abl Enzyme Substrate 1

Introduction

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Entrez Gene ID

Human	91768
Mouse	63955

UniProt ID

Human	Q8TDN4
Mouse	Q9ESJ1

Alternative Names

Cdk5 And Abl Enzyme Substrate 1; Interactor With CDK3 1; CABLES; IK3-1; CDK5 And ABL1 Enzyme Substrate 1; HsT2563; CABL1;

Function

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Regulation of cell cycle Source: InterPro

Cellular Location

Nucleus; Cytoplasm. Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity).

Hernández-Ramírez, L. C., Gam, R., Valdés, N., Lodish, M. B., Pankratz, N., Balsalobre, A., ... & Stratakis, C. A. (2017). Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing’s disease. Endocrine-related cancer, 24(8), 379-392.

Huang, J. R., Tan, G. M., Li, Y., & Shi, Z. (2017). The emerging role of Cables1 in cancer and other diseases. Molecular pharmacology, 92(3), 240-245.

Liu, J., Wang, Y., Cui, J., Sun, M., Pu, Z., Wang, C., ... & Yu, B. (2017). miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit+ cells to promote proliferation and inhibit apoptosis through a negative feedback loop. Stem cell research & therapy, 8(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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