Rabbit Anti-CABLES2 Recombinant Antibody (EG450) (CBMAB-EN510-LY)

The product is antibody recognizes CABLES2 . The antibody EG450 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000.
See all CABLES2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG450

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human Ik3-2.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cdk5 And Abl Enzyme Substrate 2

Introduction

CABLES2 (Cdk5 And Abl Enzyme Substrate 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CABLES1.

Entrez Gene ID

Human	81928
Mouse	252966

UniProt ID

Human	Q9BTV7
Mouse	Q8K3M5

Alternative Names

Cdk5 And Abl Enzyme Substrate 2; Interactor With CDK3 2; C20orf150; Ik3-2; Chromosome 20 Open Reading Frame 150; CDK5 And ABL1 Enzyme Substrate 2; DJ908M14.2;

Function

Unknown. Probably involved in G1-S cell cycle transition.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Regulation of cell cycle Source: InterPro

References

Dinh, T. T. H., Iseki, H., Mizuno, S., Iijima-Mizuno, S., Tanimoto, Y., Daitoku, Y., ... & Sugiyama, F. (2021). Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Elife, 10, e50346.

Hasan, A. S. H., Dinh, T. T. H., Le, H. T., Mizuno-Iijima, S., Daitoku, Y., Ishida, M., ... & Sugiyama, F. (2020). Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo. Experimental animals, 20-0063.

Dinh, T. T. H., Iseki, H., Mizuno, S., Iijima-Mizuno, S., Tanimoto, Y., Daitoku, Y., ... & Sugiyama, F. (2019). Cables2 Is a Novel Smad2-Regulatory Factor Essential for Early Embryonic Development in Mice. bioRxiv, 744128.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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