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Mouse Anti-CACNA1D Recombinant Antibody (CBYJL-018) (CBMAB-L0043-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Calcium Voltage-Gated Channel Subunit Alpha1 D (CACNA1D). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all CACNA1D antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJL-018
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Subunit Alpha1 D
Introduction
CACNA1D belongs to Voltage-dependent calcium channels mainly mediating the entry of calcium ions into excitable cells, and also playing a role in a variety of calcium-dependent processes, including muscle contraction, gene expressionhormone and neurotransmitter release. Calcium channels are multisubunit complexes made up of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, while the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are concerned primarily in the expression of varieties of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S.
Entrez Gene ID
Human776
Mouse12289
Rat29716
UniProt ID
HumanQ01668
MouseQ99246
RatP27732
Alternative Names
Calcium Voltage-Gated Channel Subunit Alpha1 D; Calcium Channel; Voltage-Dependent; L Type; Alpha 1D Subunit; CACNL1A2; CCHL1A2; CACH3; CACN4; Calcium Channel; Neuroendocrine/Brain-Type; Alpha 1 Subunit; Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D; Calcium Channel; L Type; Alpha-1 Polypeptide; Isoform 2
Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: BHF-UCL
Calcium ion import Source: BHF-UCL
Calcium ion transmembrane transport Source: BHF-UCL
Calcium ion transport Source: UniProtKB
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
Membrane depolarization during SA node cell action potential Source: BHF-UCL
Positive regulation of adenylate cyclase activity Source: UniProtKB
Positive regulation of calcium ion transport Source: BHF-UCL
Regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of insulin secretion Source: Reactome
Regulation of potassium ion transmembrane transport Source: BHF-UCL
Regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Sensory perception of sound Source: BHF-UCL
Cellular Location
Membrane
Involvement in disease
Sinoatrial node dysfunction and deafness (SANDD): A disease characterized by congenital severe to profound deafness without vestibular dysfunction, associated with episodic syncope due to intermittent pronounced bradycardia.
Primary aldosteronism, seizures, and neurologic abnormalities (PASNA): A disorder characterized by hypertension, hypokalemia, and high aldosterone levels with low plasma renin activity and an elevated aldosterone/renin ratio. Other features include generalized seizures, cerebral palsy, spasticity, intellectual disability, and developmental delay.
Topology
Cytoplasmic: 1-126 aa
Helical: 127-145 aa
Extracellular: 146-163 aa
Helical: 164-183 aa
Cytoplasmic: 184-195 aa
Helical: 196-214 aa
Extracellular: 215-235 aa
Helical: 236-254 aa
Cytoplasmic: 255-273 aa
Helical: 274-293 aa
Extracellular: 294-381 aa
Helical: 382-406 aa
Cytoplasmic: 407-523 aa
Helical: 524-543 aa
Extracellular: 544-558 aa
Helical: 559-577 aa
Cytoplasmic: 578-585 aa
Helical: 586-604 aa
Extracellular: 605-614 aa
Helical: 615-633 aa
Cytoplasmic: 634-652 aa
Helical: 653-673 aa
Extracellular: 674-727 aa
Helical: 728-752 aa
Cytoplasmic: 753-886 aa
Helical: 887-905 aa
Extracellular: 906-921 aa
Helical: 922-941 aa
Cytoplasmic: 942-953 aa
Helical: 954-972 aa
Extracellular: 973-978 aa
Helical: 979-998 aa
Cytoplasmic: 999-1017 aa
Helical: 1018-1037 aa
Extracellular: 1038-1127 aa
Helical: 1128-1148 aa
Cytoplasmic: 1149-1205 aa
Helical: 1206-1224 aa
Extracellular: 1225-1239 aa
Helical: 1240-1259 aa
Cytoplasmic: 1260-1266 aa
Helical: 1267-1288 aa
Extracellular: 1289-1313 aa
Helical: 1314-1333 aa
Cytoplasmic: 1334-1352 aa
Helical: 1353-1372 aa
Extracellular: 1373-1439 aa
Helical: 1440-1464 aa
Cytoplasmic: 1465-2161 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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