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Mouse Anti-CACNA1D Recombinant Antibody (CBYJL-018) (CBMAB-L0043-YJ)

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Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
CBYJL-018
Application
WB, IP, IF, IH
Immunogen
Fusion protein amino acids 859-875 of rat Cav1.3.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:100
IHC1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Calcium Voltage-Gated Channel Subunit Alpha1 D
Introduction
CACNA1D belongs to Voltage-dependent calcium channels mainly mediating the entry of calcium ions into excitable cells, and also playing a role in a variety of calcium-dependent processes, including muscle contraction, gene expressionhormone and neurotransmitter release. Calcium channels are multisubunit complexes made up of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, while the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are concerned primarily in the expression of varieties of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S.
Entrez Gene ID
Human776
Mouse12289
Rat29716
UniProt ID
HumanQ01668
MouseQ99246
RatP27732
Alternative Names
Calcium Voltage-Gated Channel Subunit Alpha1 D; Calcium Channel; Voltage-Dependent; L Type; Alpha 1D Subunit; CACNL1A2; CCHL1A2; CACH3; CACN4; Calcium Channel; Neuroendocrine/Brain-Type; Alpha 1 Subunit; Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D; Calcium Channel; L Type; Alpha-1 Polypeptide; Isoform 2
Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: BHF-UCL
Calcium ion import Source: BHF-UCL
Calcium ion transmembrane transport Source: BHF-UCL
Calcium ion transport Source: UniProtKB
Cardiac muscle cell action potential involved in contraction Source: BHF-UCL
Membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
Membrane depolarization during SA node cell action potential Source: BHF-UCL
Positive regulation of adenylate cyclase activity Source: UniProtKB
Positive regulation of calcium ion transport Source: BHF-UCL
Regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
Regulation of heart rate by cardiac conduction Source: BHF-UCL
Regulation of insulin secretion Source: Reactome
Regulation of potassium ion transmembrane transport Source: BHF-UCL
Regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
Sensory perception of sound Source: BHF-UCL
Cellular Location
Membrane
Involvement in disease
Sinoatrial node dysfunction and deafness (SANDD): A disease characterized by congenital severe to profound deafness without vestibular dysfunction, associated with episodic syncope due to intermittent pronounced bradycardia.
Primary aldosteronism, seizures, and neurologic abnormalities (PASNA): A disorder characterized by hypertension, hypokalemia, and high aldosterone levels with low plasma renin activity and an elevated aldosterone/renin ratio. Other features include generalized seizures, cerebral palsy, spasticity, intellectual disability, and developmental delay.
Topology
Cytoplasmic: 1-126 aa
Helical: 127-145 aa
Extracellular: 146-163 aa
Helical: 164-183 aa
Cytoplasmic: 184-195 aa
Helical: 196-214 aa
Extracellular: 215-235 aa
Helical: 236-254 aa
Cytoplasmic: 255-273 aa
Helical: 274-293 aa
Extracellular: 294-381 aa
Helical: 382-406 aa
Cytoplasmic: 407-523 aa
Helical: 524-543 aa
Extracellular: 544-558 aa
Helical: 559-577 aa
Cytoplasmic: 578-585 aa
Helical: 586-604 aa
Extracellular: 605-614 aa
Helical: 615-633 aa
Cytoplasmic: 634-652 aa
Helical: 653-673 aa
Extracellular: 674-727 aa
Helical: 728-752 aa
Cytoplasmic: 753-886 aa
Helical: 887-905 aa
Extracellular: 906-921 aa
Helical: 922-941 aa
Cytoplasmic: 942-953 aa
Helical: 954-972 aa
Extracellular: 973-978 aa
Helical: 979-998 aa
Cytoplasmic: 999-1017 aa
Helical: 1018-1037 aa
Extracellular: 1038-1127 aa
Helical: 1128-1148 aa
Cytoplasmic: 1149-1205 aa
Helical: 1206-1224 aa
Extracellular: 1225-1239 aa
Helical: 1240-1259 aa
Cytoplasmic: 1260-1266 aa
Helical: 1267-1288 aa
Extracellular: 1289-1313 aa
Helical: 1314-1333 aa
Cytoplasmic: 1334-1352 aa
Helical: 1353-1372 aa
Extracellular: 1373-1439 aa
Helical: 1440-1464 aa
Cytoplasmic: 1465-2161 aa

Levin, A. S. (2021). Linking Magnetoreception to CACNA1D Homolog Protein Insertions in Vertebrates.

Banono, N. S., Gawel, K., De Witte, L., & Esguerra, C. V. (2021). Zebrafish larvae carrying a splice variant mutation in cacna1d: a new model for schizophrenia-like behaviours?. Molecular neurobiology, 58(2), 877-894.

Yang, Y. D., Song, J. Y., Wang, S., Wang, Y., Song, Q. Y., Dong, Y. H., ... & Ma, J. (2019). Combined effects of the rs9810888 polymorphism in calcium voltage-gated channel subunit alpha1 D (CACNA1D) and lifestyle behaviors on blood pressure level among Chinese children. PloS one, 14(5), e0216950.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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