Mouse Anti-CACNB1 Recombinant Antibody (3H6) (CBMAB-C2265-CQ)

Name: Mouse Anti-CACNB1 Recombinant Antibody (3H6)
SKU: CBMAB-C2265-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3H6

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-269 of human CACNB1 produced in E.coli.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1

Introduction

CACNB1 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1) is a Protein Coding gene. Diseases associated with CACNB1 include Malignant Hyperthermia and Malignant Hyperthermia Susceptibility. Among its related pathways are Cardiac conduction and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and high voltage-gated calcium channel activity. An important paralog of this gene is CACNB2.

Entrez Gene ID

Human	782
Mouse	12295
Rat	50688

UniProt ID

Human	Q02641
Mouse	Q8R3Z5
Rat	P54283

Alternative Names

Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1; Calcium Channel, Voltage-Dependent, Beta 1 Subunit; Calcium Channel Voltage-Dependent Subunit Beta 1; CACNLB1; CAB1; Dihydropyridine-Sensitive L-Type, Calcium Channel Beta-1 Subunit; Voltage-Dependent L-Type Calcium Channel Subunit Beta-1; Calcium Channel, L Type, Beta 1 Polypeptide; CCHLB1;

Function

Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847).
Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity).
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847).
Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651).
Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).

Biological Process

Cardiac conduction Source: Reactome
Cellular response to amyloid-beta Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Neuromuscular junction development Source: GO_Central
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: ARUK-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central

Cellular Location

Sarcolemma; Cell membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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