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Mouse Anti-CACNG3 Recombinant Antibody (CBYY-C0862) (CBMAB-C2298-YY)

This product is mouse antibody that recognizes CACNG3. The antibody CBYY-C0862 can be used for immunoassay techniques such as: ELISA, WB
See all CACNG3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYY-C0862
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa199-297 from CACNG3 (NP_006530) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
calcium channel, voltage-dependent, gamma subunit 3
Entrez Gene ID
Human10368
Rat140724
UniProt ID
HumanO60359
RatQ8VHX0
Alternative Names
Calcium Binding And Coiled-Coil Domain 2; Antigen Nuclear Dot 52 KDa Protein; Nuclear Domain 10 Protein NDP52; Nuclear Domain 10 Protein 52; Nuclear Dot Protein 52; NDP52; Calcium-Binding And Coiled-Coil Domain-Containing Protein 2;
Function
Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Biological Process
Calcium ion transport Source: UniProtKB
Neurotransmitter receptor internalization Source: GO_Central
Neurotransmitter receptor transport, postsynaptic endosome to lysosome Source: GO_Central
Positive regulation of AMPA receptor activity Source: Ensembl
Positive regulation of synaptic transmission, glutamatergic Source: GO_Central
Postsynaptic neurotransmitter receptor diffusion trapping Source: GO_Central
Protein localization Source: UniProtKB
Protein targeting Source: UniProtKB
Regulation of AMPA receptor activity Source: UniProtKB
Transmission of nerve impulse Source: GO_Central
Cellular Location
Membrane. Displays a somatodendritic localization and is excluded from axons in neurons.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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