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Rabbit Anti-CARD10 Recombinant Antibody (EG478) (CBMAB-EN542-LY)

The product is antibody recognizes CARD10 . The antibody EG478 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000.
See all CARD10 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG478
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CARD10.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Caspase Recruitment Domain Family Member 10
Introduction
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human29775
Mouse105844
UniProt ID
HumanQ9BWT7
MouseP58660
Alternative Names
Caspase Recruitment Domain Family Member 10; CARD-Containing MAGUK Protein 3; Carma 3; CARMA3; Caspase Recruitment Domain-Containing Protein 10; Caspase Recruitment Domain Family, Member 10; Bcl10 Binding Protein And Activator Of NFKB; CARD-Containing MAGUK 3 Protein; BIMP1;
Function
Activates NF-kappa-B via BCL10 and IKK.
Biological Process
Activation of NF-kappaB-inducing kinase activity Source: UniProtKB
Negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Positive regulation of protein localization to nucleus Source: BHF-UCL
Protein-containing complex assembly Source: UniProtKB
Regulation of apoptotic process Source: InterPro
Cellular Location
Cytoplasm

Israël, L., Glück, A., Berger, M., Coral, M., Ceci, M., Unterreiner, A., ... & Bornancin, F. (2021). CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo. Oncogenesis, 10(4), 1-11.

Yang, D. H., Guo, T., Yuan, Z. Z., Lei, C., Ding, S. Z., Yang, Y. F., ... & Luo, H. (2020). Mutant CARD10 in a family with progressive immunodeficiency and autoimmunity. Cellular & molecular immunology, 17(7), 782-784.

Zhang, C., Wang, H., & Yang, B. (2020). miR-146a regulates inflammation and development in patients with abdominal aortic aneurysms by targeting CARD10. International angiology: a journal of the International Union of Angiology.

Peng, L., He, K., Cao, Z., Bi, L., Yu, D., Wang, Q., & Wang, J. (2020). CARD10 promotes the progression of renal cell carcinoma by regulating the NF‑κB signaling pathway. Molecular medicine reports, 21(1), 329-337.

Motawi, T. K., El-Maraghy, S. A., Sharaf, S. A., & Said, S. E. (2019). Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis. Journal of advanced research, 15, 103-110.

Liu, X., Zhang, X., Bi, J., Li, Z., Zhang, Z., & Kong, C. (2019). Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells. Journal of cellular and molecular medicine, 23(12), 8128-8138.

Israël, L., Bardet, M., Huppertz, A., Mercado, N., Ginster, S., Unterreiner, A., ... & Bornancin, F. (2018). A CARD10-dependent tonic signalosome activates MALT1 paracaspase and regulates IL-17/TNF-α-driven keratinocyte inflammation. The Journal of investigative dermatology, 138(9), 2075-2079.

Yamamoto-Furusho, J. K., Fonseca-Camarillo, G., Furuzawa-Carballeda, J., Sarmiento-Aguilar, A., Barreto-Zuñiga, R., Martínez-Benitez, B., & Lara-Velazquez, M. A. (2018). Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease. Journal of Inflammation, 15(1), 1-12.

Zou, Y., Zhou, J. Y., Wang, F., Zhang, Z. Y., Liu, F. Y., Luo, Y., ... & Huang, O. P. (2018). Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis. Oncology letters, 16(1), 491-496.

Shyamsunder, P., Sankar, H., Mayakonda, A., Han, L., Nordin, H. B. M., Woon, T. W., ... & Koeffler, H. P. (2018). CARD10, a CEBPE target involved in granulocytic differentiation. haematologica, 103(8), 1269.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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