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Mouse Anti-CAVIN3 Recombinant Antibody (8D3) (CBMAB-P0142-YC)

Provided herein is a Mouse monoclonal antibody against Human Caveolae Associated Protein 3. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all CAVIN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8D3
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PRKCDBP (NP_659477, 161-261 aa) partial recombinant protein with GST tag. Immunogen sequence: EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA EEALLQMESV A
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 161-261

Target

Full Name
Caveolae Associated Protein 3
Introduction
CAVIN3 was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein.
Entrez Gene ID
112464
UniProt ID
Q969G5
Alternative Names
CAVIN3; cavin-3; SRBC; HSRBC
Function
Regulates the traffic and/or budding of caveolae (PubMed:19262564).
Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
Biological Process
Circadian regulation of gene expression Source: UniProtKB
Cellular Location
Cytoplasm; Cytosol; Caveola. Localizes in the caveolae in a caveolin-dependent manner.
PTM
In vitro, phosphorylated by PRKCD.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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