Mouse Anti-CBY1 Recombinant Antibody (2F2) (CBMAB-C5067-LY)

Name: Mouse Anti-CBY1 Recombinant Antibody (2F2)
SKU: CBMAB-C5067-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F2

Application

ELISA, WB

Immunogen

CBY1 (18 a.a. ~ 126 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Chibby Family Member 1, Beta Catenin Antagonist

Introduction

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

25776

UniProt ID

Q9Y3M2

Alternative Names

Chibby Family Member 1, Beta Catenin Antagonist; PKD2 Interactor, Golgi And Endoplasmic Reticulum-Associated 1; Chibby CTNNB1-Mediated Transcription Inhibitor; Cytosolic Leucine-Rich Protein; ARPP-Binding Protein; PIGEA-14; C22orf2; PGEA1; ARB1; CBY;

Function

Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.

Biological Process

Cardiac muscle cell differentiation Source: UniProtKB
Cell projection organization Source: UniProtKB-KW
Fat cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: UniProtKB
Protein homotetramerization Source: CAFA
Protein localization Source: UniProtKB

Cellular Location

Golgi apparatus; Trans-Golgi network; Cilium basal body; Centriole; Nucleus speckle

Guo, L., Beck, T., Fulmer, D., Ramos‐Ortiz, S., Glover, J., Wang, C., ... & Norris, R. A. (2021). DZIP1 regulates mammalian cardiac valve development through a Cby1‐β‐catenin mechanism. Developmental Dynamics.

Wen, S., Qin, Y., Wang, R., Yang, L., Zeng, H., Zhu, P., ... & Tu, G. (2021). A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels. Cell death & disease, 12(5), 1-14.

Mancini, M., Soverini, S., Gugliotta, G., Santucci, M. A., Rosti, G., Cavo, M., ... & Castagnetti, F. (2017). Chibby 1: a new component of β-catenin-signaling in chronic myeloid leukemia. Oncotarget, 8(50), 88244.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CBY1 Matched Antibody Pair (194) (CAT#: APMAB-194LY)

Related Products

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CBY1 Matched Antibody Pair (194) (CAT#: APMAB-194LY)

Mouse Anti-CBY1 Recombinant Antibody (C2325) (CAT#: CBMAB-C2325-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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