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Rabbit Anti-CC2D1A Recombinant Antibody (0205) (CBMAB-0205-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
0205
Antibody Isotype
IgG
Application
IHC-P

Basic Information

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 750-951 of human CC2D1A.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 50% glycerol, 0.05% BSA
Preservative
0.02% sodium azide
Concentration
1.5 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CC2D1A
Introduction
CC2D1A (coiled-coil and c2 domain containing 1A) is a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium.
Entrez Gene ID
54862
UniProt ID
Q6P1N0
Alternative Names
MRT3; FREUD-1; Freud-1/Aki1
Function
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity).

Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
Biological Process
Negative regulation of snRNA transcription by RNA polymerase II Source: GO_Central
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Centrosome; Nucleus; Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 3 (MRT3): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
PTM
Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21.
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For research use only. Not intended for any clinical use.

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