Rabbit Anti-CC2D1A Recombinant Antibody (0205) (CBMAB-0205-YC)

Name: Rabbit Anti-CC2D1A Recombinant Antibody (0205)
SKU: CBMAB-0205-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

0205

Application

IHC-P

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 750-951 of human CC2D1A.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC-P	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol, 0.05% BSA

Preservative

0.02% sodium azide

Concentration

1.5 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CC2D1A

Introduction

CC2D1A (coiled-coil and c2 domain containing 1A) is a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium.

Entrez Gene ID

54862

UniProt ID

Q6P1N0

Alternative Names

MRT3; FREUD-1; Freud-1/Aki1

Function

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity).

Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.

Biological Process

Negative regulation of snRNA transcription by RNA polymerase II Source: GO_Central
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Centrosome; Nucleus; Cytoplasm

Involvement in disease

Mental retardation, autosomal recessive 3 (MRT3): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

PTM

Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21.

Kumar, S., Oien, D. B., Khurana, A., Cliby, W., Hartmann, L., Chien, J., & Shridhar, V. (2019). Coiled-coil and C2 domain-containing protein 1A (CC2D1A) promotes chemotherapy resistance in ovarian cancer. Frontiers in oncology, 9, 986.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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