Mouse Anti-CCDC114 Recombinant Antibody (CBXC-1775) (CBMAB-C5618-CQ)

This product is a mouse antibody that recognizes CCDC114. The antibody CBXC-1775 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CCDC114 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-1775

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Coiled-Coil Domain Containing 114

Introduction

This gene encodes a coiled-coil domain-containing protein that is a component of the outer dynein arm docking complex in cilia cells. Mutations in this gene may cause primary ciliary dyskinesia 20.

Entrez Gene ID

93233

UniProt ID

Q96M63

Alternative Names

Coiled-Coil Domain Containing 114; Coiled-Coil Domain-Containing Protein 114; CILD20;

Function

Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule.

Biological Process

Cilium movement Source: SYSCILIA_CCNET
Outer dynein arm assembly Source: UniProtKB

Cellular Location

Cilium axoneme; Cilium

Involvement in disease

Ciliary dyskinesia, primary, 20 (CILD20): A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Unlike other forms of CILD characterized by reduced fertility, patients with CILD20 do not appear to be infertile.

References

Lv, Y., Liu, Y., Wang, Y., Kong, F., Pang, Q., & Hu, G. (2021). CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium. BMC Women's Health, 21(1), 1-10.

Chen, X., Deng, S., Xia, H., Yuan, L., Xu, H., Tang, S., & Deng, H. (2020). Identification of a CCDC114 variant in a Han-Chinese patient with situs inversus. Experimental and Therapeutic Medicine, 20(4), 3336-3342.

Li, P., He, Y., Cai, G., Xiao, F., Yang, J., Li, Q., & Chen, X. (2019). CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease. Journal of human genetics, 64(1), 39-48.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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