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Mouse Anti-CCDC115 Recombinant Antibody (4E9) (CBMAB-C6895-LY)

This product is antibody recognizes CCDC115. The antibody 4E9 immunoassay techniques such as: ELISA, IHC-P, WB.
See all CCDC115 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E9
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
CCDC115 (AAH06429.1, 1 a.a. ~ 132 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
coiled-coil domain containing 115
Introduction
The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016]
Entrez Gene ID
84317
UniProt ID
Q96NT0
Alternative Names
Coiled-Coil Domain Containing 115; Coiled-Coil Domain-Containing Protein 115; CDG2O; CCP1;
Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633).
May be involved in Golgi homeostasis (PubMed:26833332).
Biological Process
Cellular iron ion homeostasis Source: UniProtKB
Cellular response to increased oxygen levels Source: UniProtKB
Lysosomal lumen acidification Source: UniProtKB
Lysosomal protein catabolic process Source: UniProtKB
Vacuolar proton-transporting V-type ATPase complex assembly Source: InterPro
Cellular Location
Endosome; Lysosome; Endoplasmic reticulum; Endoplasmic reticulum-Golgi intermediate compartment; COPI-coated vesicle
Involvement in disease
Congenital disorder of glycosylation 2O (CDG2O): A form of congenital disorder of glycosylation, a genetically heterogeneous group of autosomal recessive, multisystem disorders caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG2O is characterized by hepatosplenomegaly, liver failure, hypotonia, and psychomotor disability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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