Mouse Anti-CCDC69 Recombinant Antibody (CBYY-C1050) (CBMAB-C2487-YY)

This product is mouse antibody that recognizes CCDC69. The antibody CBYY-C1050 can be used for immunoassay techniques such as: ELISA, WB
See all CCDC69 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C1050

Application

ELISA, WB

Basic Information

Immunogen

CCDC69 (NP_056436.2, aa1-296) full-length recombinant protein with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative

PBS, pH 7.4

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

coiled-coil domain containing 69

Entrez Gene ID

26112

UniProt ID

A6NI79

Function

May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.

Biological Process

Spindle midzone assembly Source: UniProtKB

Cellular Location

Spindle; Midbody. During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.

References

Li, J., Zhang, P., & Xia, Y. (2021). Aberrant expression of CCDC69 in breast cancer and its clinicopathologic significance. European Journal of Histochemistry: EJH, 65(1).

Li, J., Zheng, P., & Xia, Y. (2021). Study on CCDC69 interfering with the prognosis of patients with breast cancer through PPAR signal pathway. European Journal of Histochemistry, 65(1).

Cui, L., Zhou, F., Chen, C., & Wang, C. C. (2019). Overexpression of CCDC69 activates p14 ARF/MDM2/p53 pathway and confers cisplatin sensitivity. Journal of ovarian research, 12(1), 1-8.

Chowdhury, A. (2019). In Silico Study Predicts CCDC69 as a Novel Tumour Suppressor Gene in HER2+ Breast Cancer. Journal of Human Physiology| Volume, 1(02).

Cui, L., Liang, B., Yang, Y., Zhu, M., Kwong, J., Zheng, H., & Wang, C. C. (2017). Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells. Oncotarget, 8(60), 101634.

Cui, L., Bo, L., Yang, Y., Zhu, M., Kwong, J., Zheng, H., & Wang, C. C. (2017). Inhibition of coiled coil domain containing protein 69 (CCDC69) enhance platinum-mediated apoptosis in ovarian cancer cells.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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