Mouse Anti-CCNB1IP1 Recombinant Antibody (4H3) (CBMAB-C7037-LY)

Name: Mouse Anti-CCNB1IP1 Recombinant Antibody (4H3)
SKU: CBMAB-C7037-LY
Rating: 5 (1 reviews)

See all CCNB1IP1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4H3

Application

WB, FC, IHC

Immunogen

Full length human recombinant protein of human CCNB1IP1 produced in E.coli

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500
IHC	1:150
FC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cyclin B1 Interacting Protein 1

Introduction

CCNB1IP1 (Cyclin B1 Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include ligase activity.

Entrez Gene ID

57820

UniProt ID

Q9NPC3

Alternative Names

Cyclin B1 Interacting Protein 1; Human Enhancer Of Invasion 10; Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase CCNB1IP1; C14orf18; HEI10;

Function

Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity).
Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

Biological Process

Chiasma assembly Source: UniProtKB
Reciprocal meiotic recombination Source: UniProtKB

Cellular Location

Nucleus; Chromosome. Associates to the synaptonemal complex.

PTM

Ubiquitinated; autoubiquitinated.
Phosphorylated by CDK1 on serine or threonine residues (in vitro).

Islam, I., Baba, Y., Witarto, A. B., & Yoshida, W. (2019). G-quadruplex–forming GGA repeat region functions as a negative regulator of the Ccnb1ip1 enhancer. Bioscience, biotechnology, and biochemistry, 83(9), 1697-1702.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-CCNB1IP1 Recombinant Antibody (4H3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry