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Mouse Anti-CCNB1IP1 Recombinant Antibody (4H3) (CBMAB-C7037-LY)

This product is antibody recognizes CCNB1IP1. The antibody 4H3 immunoassay techniques such as: WB, FC, IHC, IHC-P.
See all CCNB1IP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H3
Antibody Isotype
IgG1
Application
WB, FC, IHC, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human CCNB1IP1 (NP_878269) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin B1 Interacting Protein 1
Introduction
CCNB1IP1 (Cyclin B1 Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include ligase activity.
Entrez Gene ID
57820
UniProt ID
Q9NPC3
Alternative Names
Cyclin B1 Interacting Protein 1; Human Enhancer Of Invasion 10; Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase CCNB1IP1; C14orf18; HEI10;
Function
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity).
Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Biological Process
Chiasma assembly Source: UniProtKB
Reciprocal meiotic recombination Source: UniProtKB
Cellular Location
Nucleus; Chromosome. Associates to the synaptonemal complex.
PTM
Ubiquitinated; autoubiquitinated.
Phosphorylated by CDK1 on serine or threonine residues (in vitro).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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