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Rat Anti-CCT8 Recombinant Antibody (CBYJT-1085) (CBMAB-T0095-YJ)

Provided herein is a Rat monoclonal antibody, which binds to CCT8 (Chaperonin Containing TCP1 Subunit 8). The antibody can be used for immunoassay techniques, such as IP, WB.
See all CCT8 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse, Rabbit, Cattle
Clone
CBYJT-1085
Antibody Isotype
IgG2a
Application
IP, WB

Basic Information

Specificity
Human, Mouse, Rabbit, Cattle
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chaperonin Containing TCP1 Subunit 8
Introduction
CCT8 (Chaperonin Containing TCP1 Subunit 8) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Innate Immune System. Gene Ontology (GO) annotations related to CCT8 include unfolded protein binding and ATPase activity, coupled. An important paralog of CCT8 is CCT8L2.
Entrez Gene ID
Human10694
Mouse12469
Cattle281047
Rabbit100353291
UniProt ID
HumanP50990
MouseP42932
CattleQ3ZCI9
RabbitG1SHZ8
Alternative Names
Chaperonin Containing TCP1 Subunit 8; Chaperonin Containing TCP1, Subunit 8 (Theta); Renal Carcinoma Antigen NY-REN-15; TCP-1-Theta; C21orf112; CCT-Theta; Cctq
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Binding of sperm to zona pellucida Source: Ensembl
Neutrophil degranulation Source: Reactome
Pore complex assembly Source: Ensembl
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Toxin transport Source: Ensembl
Cellular Location
Centrosome; Cilium basal body; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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