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Mouse Anti-CD5L Recombinant Antibody (1C8) (CBMAB-C3776-LY)

This product is antibody recognizes CD5L. The antibody 1C8 immunoassay techniques such as: ELISA, WB, IP.
See all CD5L antibodies
Published Data
Fig.1 CD5L protein levels in liver cancer are associated with patient outcome.
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Fig.2 Representative confocal microscopy images showing CD5L staining.
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Fig.3 HSPA5 is a new ligand for CD5L.
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Fig.4 MVs show considerable variation in protein composition.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IP

Basic Information

Immunogen
Recognizes human CD5L
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD5 Molecule Like
Introduction
CD5L (CD5 Molecule Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.
Entrez Gene ID
922
UniProt ID
O43866
Alternative Names
CD5 Molecule Like; CD5 Antigen-Like (Scavenger Receptor Cysteine Rich Family); Apoptosis Inhibitor Expressed By Macrophages; IgM-Associated Peptide; Apoptosis Inhibitor 6; SP-ALPHA; API6; CT-2;
Function
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity).
Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828).
Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cellular defense response Source: ProtInc
Immune system process Source: UniProtKB-KW
Inflammatory response Source: UniProtKB-KW
Positive regulation of complement-dependent cytotoxicity Source: Ensembl
Regulation of complement activation Source: Ensembl
Zymogen activation Source: GO_Central
Cellular Location
Secreted; Cytoplasm. Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity).
PTM
Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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