Mouse Anti-CDC23 Recombinant Antibody (C4042) (CBMAB-C4042-LY)

Name: Mouse Anti-CDC23 Recombinant Antibody (C4042)
SKU: CBMAB-C4042-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

C4042

Application

ELISA, WB, IF

Immunogen

IYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKC CAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPAS LSANNTPTRRVSPLNLSSVTP

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cell Division Cycle 23

Introduction

CDC23 (Cell Division Cycle 23) is a Protein Coding gene. Among its related pathways are PAK Pathway and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

Entrez Gene ID

8697

UniProt ID

Q9UJX2

Alternative Names

Cell Division Cycle 23; Anaphase-Promoting Complex Subunit 8; Cyclosome Subunit 8; ANAPC8; APC8; CDC23 (Cell Division Cycle 23, Yeast, Homolog);

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Biological Process

Anaphase-promoting complex-dependent catabolic process Source: GO_Central
Cell division Source: GO_Central
Metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
Mitotic cell cycle Source: UniProtKB
Mitotic metaphase plate congression Source: UniProtKB
Positive regulation of mitotic metaphase/anaphase transition Source: GO_Central
Protein K11-linked ubiquitination Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of exit from mitosis Source: Reactome
Regulation of mitotic cell cycle phase transition Source: Reactome
Regulation of mitotic metaphase/anaphase transition Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: Reactome

Cellular Location

Cytosol; Anaphase-promoting complex; Nucleoplasm; Cytoplasm

PTM

Phosphorylated. Phosphorylation on Thr-562 ^oCcurs specifically during mitosis.

Zhou, Q., Li, J., Yue, W., Li, A., Meng, T. G., Lei, W. L., ... & Sun, Q. Y. (2020). Cell division cycle 23 is required for mouse oocyte meiotic maturation. The FASEB Journal, 34(7), 8990-9002.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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