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Mouse Anti-CDCA3 Recombinant Antibody (CBXC-0299) (CBMAB-C5637-CQ)

This product is a mouse antibody that recognizes CDCA3. The antibody CBXC-0299 can be used for immunoassay techniques such as: S-ELISA, ELISA, WB.
See all CDCA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0299
Antibody Isotype
IgG2b, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
CDCA3 (AAH02551, 1 a.a.-268 a.a) Full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Division Cycle Associated 3
Introduction
CDCA3 (Cell Division Cycle Associated 3) is a Protein Coding gene. Among its related pathways are Cell cycle_Role of APC in cell cycle regulation.
Entrez Gene ID
83461
UniProt ID
Q99618
Alternative Names
Cell Division Cycle Associated 3; Trigger Of Mitotic Entry Protein 1; Gene-Rich Cluster Protein C8; TOME-1; GRCC8; Cell Division Cycle-Associated Protein 3; Trigger Of Mitotic Entry 1; TOME1; C8;
Function
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Cytosol
PTM
Ubiquitinated and degraded by the APC/C-Cdh1 complex.

Li, K., Li, S., Tang, S., Zhang, M., Ma, Z., Wang, Q., & Chen, F. (2021). KIF22 promotes bladder cancer progression by activating the expression of CDCA3. International journal of molecular medicine, 48(6), 1-13.

Sahin, K. B., Shah, E. T., Ferguson, G. P., Molloy, C., Kalita-de Croft, P., Hayes, S. A., ... & Adams, M. N. (2021). Elevating CDCA3 levels enhances tyrosine kinase inhibitor sensitivity in TKI-resistant EGFR mutant non-small-cell lung cancer. Cancers, 13(18), 4651.

Yu, J., Hua, R., Zhang, Y., Tao, R., Wang, Q., & Ni, Q. (2020). DNA hypomethylation promotes invasion and metastasis of gastric cancer cells by regulating the binding of SP1 to the CDCA3 promoter. Journal of cellular biochemistry, 121(1), 142-151.

Zhang, Y., Yin, W., Cao, W., Chen, P., Bian, L., & Ni, Q. (2019). CDCA3 is a potential prognostic marker that promotes cell proliferation in gastric cancer. Oncology reports, 41(4), 2471-2481.

Bi, L., Zhou, B., Li, H., He, L., Wang, C., Wang, Z., ... & Gao, S. (2018). A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia. BMC cancer, 18(1), 1-17.

Qian, W., Zhang, Z., Peng, W., Li, J., Gu, Q., Ji, D., ... & Sun, Y. (2018). CDCA3 mediates p21-dependent proliferation by regulating E2F1 expression in colorectal cancer. International journal of oncology, 53(5), 2021-2033.

Zhang, W., Lu, Y., Li, X., Zhang, J., Zheng, L., Zhang, W., ... & Li, X. (2018). CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer. Biochemical and biophysical research communications, 500(2), 196-203.

Phan, N. N., Wang, C. Y., Li, K. L., Chen, C. F., Chiao, C. C., Yu, H. G., ... & Lin, Y. C. (2018). Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient. Oncotarget, 9(6), 6977.

Adams, M. N., Burgess, J. T., He, Y., Gately, K., Snell, C., Zhang, S. D., ... & O’Byrne, K. J. (2017). Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non–small cell lung cancer. Journal of Thoracic Oncology, 12(7), 1071-1084.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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