Rat Anti-CDH12 Recombinant Antibody (CBXC-1123) (CBMAB-C1389-CQ)

Name: Rat Anti-CDH12 Recombinant Antibody (CBXC-1123)
SKU: CBMAB-C1389-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXC-1123

Application

WB, FC, IF

Immunogen

Recombinant human Cadherin-12 Met1-Pro609.

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	8-25 µg/ml
WB	1 µg/ml
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Cadherin 12

Introduction

CDH12 (Cadherin 12) is a Protein Coding gene. Diseases associated with CDH12 include Cri-Du-Chat Syndrome. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH6.

Entrez Gene ID

1010

UniProt ID

P55289

Alternative Names

Cadherin 12; Neural Type Cadherin 2; N-Cadherin 2; Br-Cadherin; Cadherin 12, Type 2 (N-Cadherin 2); Cadherin, Neural Type, 2;

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 55-609
Helical: 610-637
Cytoplasmic: 638-794

Guo, B., Qi, M., Huang, S., Zhuo, R., Zhang, W., Zhang, Y., ... & Liu, Y. (2021). Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1/Cdc42 Pathway in Cortical Neurons. Frontiers in Cell and Developmental Biology, 9.

Stone, L. (2021). CDH12-expressing cell population predicts patient response to therapy. Nature Reviews Urology, 1-1.

van der Zanden, L. F., van Rooij, I. A., Quaedackers, J. S., Nijman, R. J., Steffens, M., de Wall, L. L., ... & Feitz, W. F. (2021). CDH12 as a candidate gene for kidney injury in posterior urethral valve cases: a genome-wide association study among patients with obstructive uropathies. European Urology Open Science, 28, 26-35.

Charfeddine, C., Dallali, H., Abdessalem, G., Ghedira, K., Hamdi, Y., Elouej, S., ... & Mokni, M. (2020). Identification of a CDH12 potential candidate genetic variant for an autosomal dominant form of transgrediens and progrediens palmoplantar keratoderma in a Tunisian family. Journal of human genetics, 65(4), 397-410.

Chen, C. P., Chang, S. Y., Lin, C. J., Chern, S. R., Wu, P. S., Chen, S. W., ... & Wang, W. (2018). Prenatal diagnosis of a familial 5p14. 3-p14. 1 deletion encompassing CDH18, CDH12, PMCHL1, PRDM9 and CDH10 in a fetus with congenital heart disease on prenatal ultrasound. Taiwanese Journal of Obstetrics and Gynecology, 57(5), 734-738.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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