Mouse Anti-CDK20 Recombinant Antibody (885CT27.1.1) (CBMAB-C9006-LY)

Name: Mouse Anti-CDK20 Recombinant Antibody (885CT27.1.1)
SKU: CBMAB-C9006-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

885CT27.1.1

Application

WB, IP

Immunogen

His-tagged CCRK protein fragment of human.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cyclin Dependent Kinase 20

Introduction

CDK20 (Cyclin Dependent Kinase 20) is a Protein Coding gene. Diseases associated with CDK20 include Attention Deficit-Hyperactivity Disorder and Seizure Disorder. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK7.

Entrez Gene ID

23552

UniProt ID

Q8IZL9

Alternative Names

Cyclin Dependent Kinase 20; Cyclin-Kinase-Activating Kinase P42; Cyclin-Dependent Protein Kinase H; Cell Division Protein Kinase 20; Cell Cycle-Related Kinase; CDK-Activating Kinase P42; CAK-Kinase P42; EC 2.7.11.22;

Function

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity).
Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Multicellular organism development Source: UniProtKB-KW
Protein phosphorylation Source: GO_Central

Cellular Location

Nucleus; Cytoplasm; Cilium

Lai, L., Shin, G. Y., & Qiu, H. (2020). The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1. International Journal of Molecular Sciences, 21(22), 8504.

Wang, Q., Ma, J., Lu, Y., Zhang, S., Huang, J., Chen, J., ... & Xu, S. (2017). CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. Oncogene, 36(37), 5321-5330.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-CDK20 Recombinant Antibody (CBXC-0319) (CAT#: CBMAB-C5520-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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