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Rabbit Anti-CDKAL1 Recombinant Antibody (EG617) (CBMAB-EN744-LY)

The product is antibody recognizes CDKAL. The antibody EG617 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all CDKAL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
EG617
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human CDKAL.
Specificity
Human, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CDK5 Regulatory Subunit Associated Protein 1 Like 1
Entrez Gene ID
Human54901
Rat361243
UniProt ID
HumanQ5VV42
RatK9N0M9
Function
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t6A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) at position 37 in tRNAs that read codons beginning with adenine.
Biological Process
Maintenance of translational fidelity Source: Ensembl
tRNA methylthiolation Source: GO_Central
tRNA modification Source: Reactome
Cellular Location
Endoplasmic reticulum membrane. Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum.
Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM): A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Topology
Helical: 556-578
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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