Mouse Anti-CDKL1 Recombinant Antibody (3G8) (CBMAB-C6186-LY)

Name: Mouse Anti-CDKL1 Recombinant Antibody (3G8)
SKU: CBMAB-C6186-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3G8

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

CDKL1 (259 a.a. ~ 358 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cyclin Dependent Kinase Like 1

Introduction

CDKL1 (Cyclin Dependent Kinase Like 1) is a Protein Coding gene. Diseases associated with CDKL1 include Orofaciodigital Syndrome Vi. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL4.

Entrez Gene ID

8814

UniProt ID

Q00532

Alternative Names

Cyclin Dependent Kinase Like 1; Cyclin-Dependent Kinase-Like 1 (CDC2-Related Kinase); Protein Kinase P42 KKIALRE; EC 2.7.11.22; Serine/Threonine Protein Kinase KKIALRE; Serine/Threonine-Protein Kinase KKIALRE;

Biological Process

Heart development Source: Ensembl
Protein phosphorylation Source: GO_Central
Regulation of cilium assembly Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm

More Infomation

References

Shao, S., Ju, M., Lei, J., Lu, X., Li, H., Wang, D., & Xia, C. (2021). Egr‑1 inhibits colon cancer cell proliferation, migration and invasion via regulating CDKL1 at the transcriptional level. Oncology Reports, 46(2), 1-9.

Lu, M., Xiong, H., Xia, Z. K., Liu, B., Wu, F., Zhang, H. X., ... & Liu, P. (2021). circRACGAP1 promotes non-small cell lung cancer proliferation by regulating miR-144-5p/CDKL1 signaling pathway. Cancer Gene Therapy, 28(3), 197-211.

Li, W., Cao, J., Liu, J., Chu, W., Zhang, C., Chen, S., & Kang, Z. (2019). Downregulation of CDKL1 suppresses neuroblastoma cell proliferation, migration and invasion. Cellular & molecular biology letters, 24(1), 1-11.

Li, K., Meng, Z., Jiang, L., Xia, C., Xu, K., Yuan, D., ... & Liu, S. (2019). CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin. Molecular and cellular probes, 44, 57-62.

Rout, A. K., Dehury, B., Maharana, J., Nayak, C., Baisvar, V. S., Behera, B. K., & Das, B. K. (2018). Deep insights into the mode of ATP-binding mechanism in Zebrafish cyclin-dependent protein kinase-like 1 (zCDKL1): A molecular dynamics approach. Journal of Molecular Graphics and Modelling, 81, 175-183.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-CDKL1 Recombinant Antibody (2H6)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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