Sign in or Register   Sign in or Register
  |  

Mouse Anti-CDKL5 Recombinant Antibody (CBXS-4021) (CBMAB-S1282-CQ)

This product is a mouse antibody that recognizes CDKL5. The antibody CBXS-4021 can be used for immunoassay techniques such as: ELISA, WB.
See all CDKL5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4021
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cyclin-dependent kinase-like 5
Introduction
CDKL5 (Cyclin Dependent Kinase Like 5) is a Protein Coding gene. Diseases associated with CDKL5 include Epileptic Encephalopathy, Early Infantile, 2 and Rett Syndrome. Among its related pathways are Sweet Taste Signaling and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDKL2.
Entrez Gene ID
6792
UniProt ID
O76039
Alternative Names
Cyclin Dependent Kinase Like 5; Serine/Threonine-Protein Kinase 9; Cyclin-Dependent Kinase-Like 5; Serine/Threonine Kinase 9; EC 2.7.11.22; STK9;
Function
Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860).
May regulate ciliogenesis (PubMed:29420175).
Biological Process
Neuron migration Source: BHF-UCL
Positive regulation of axon extension Source: BHF-UCL
Positive regulation of dendrite morphogenesis Source: BHF-UCL
Positive regulation of dendritic spine development Source: Ensembl
Positive regulation of GTPase activity Source: BHF-UCL
Protein autophosphorylation Source: HGNC-UCL
Protein phosphorylation Source: GO_Central
Regulation of cilium assembly Source: UniProtKB
Regulation of dendrite development Source: BHF-UCL
Regulation of postsynapse organization Source: SynGO
Cellular Location
Nucleus; Cilium basal body; Centrosome
Involvement in disease
Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).
Developmental and epileptic encephalopathy 2 (DEE2): A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. However, DEE2 and Rett syndrome are considered two distinct entities.
PTM
Autophosphorylated.

Tang, Y., Wang, Z. I., Sarwar, S., Choi, J. Y., Wang, S., Zhang, X., ... & Pestana-Knight, E. (2021). Brain morphological abnormalities in children with cyclin-dependent kinase-like 5 deficiency disorder. European Journal of Paediatric Neurology, 31, 46-53.

Jhang, C. L., Lee, H. Y., Chen, J. C., & Liao, W. (2020). Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder. Human Molecular Genetics, 29(14), 2408-2419.

Katayama, S., Sueyoshi, N., Inazu, T., & Kameshita, I. (2020). Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder. Neural Plasticity, 2020.

Gao, Y., Irvine, E. E., Eleftheriadou, I., Naranjo, C. J., Hearn-Yeates, F., Bosch, L., ... & Mazarakis, N. D. (2020). Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder. Brain, 143(3), 811-832.

Katayama, S., & Inazu, T. (2019). Straightforward and rapid method for detection of cyclin-dependent kinase-like 5 activity. Analytical biochemistry, 566, 58-61.

Olson, H. E., Demarest, S. T., Pestana-Knight, E. M., Swanson, L. C., Iqbal, S., Lal, D., ... & Benke, T. A. (2019). Cyclin-dependent kinase-like 5 deficiency disorder: clinical review. Pediatric neurology, 97, 18-25.

BRC, U. G. O. S. N. (2019). Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder: clinical review Heather E. Olson Scott T. Demarest 2, Elia M. Pestana-Knight 3, Lindsay C. Swanson, Sumaiya Iqbal4, 5, Dennis Lal4, 6, Helen Leonard 7, J. Helen Cross8, Orrin Devinsky9, Tim A. Benke10 Department of Neurology, Division of Epilepsy and Clinical Neurophysiology, Boston Children’s Hospital, Boston, MA, USA.

Jhang, C. L., Huang, T. N., Hsueh, Y. P., & Liao, W. (2017). Mice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors. Human molecular genetics, 26(20), 3922-3934.

Oi, A., Katayama, S., Hatano, N., Sugiyama, Y., Kameshita, I., & Sueyoshi, N. (2017). Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). Biochemical and biophysical research communications, 482(2), 239-245.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CDKL5 Recombinant Antibody (CBXS-4021)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare