Mouse Anti-CEACAM16 Recombinant Antibody (CBFYC-1676) (CBMAB-C1738-FY)

Name: Mouse Anti-CEACAM16 Recombinant Antibody (CBFYC-1676)
SKU: CBMAB-C1738-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-1676

Application

WB, IF, ELISA, IP

Immunogen

Amino acids 317-380 mapping near the C-terminus of CEACAM16 of human.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 16

Introduction

The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss.

Entrez Gene ID

388551

UniProt ID

Q2WEN9

Alternative Names

Carcinoembryonic Antigen Related Cell Adhesion Molecule 16; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16; CEAL2; Carcinoembryonic Antigen Like-2 Protein; Carcinoembryonic Antigen-Like 2; DFNA4B

Function

Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.

Biological Process

Sensory perception of sound Source: UniProtKB

Cellular Location

Secreted. Localizes to the tip of cochlear outer hair cells and to the tectorial membrane.

Involvement in disease

Deafness, autosomal dominant, 4B (DFNA4B): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Deafness, autosomal recessive, 113 (DFNB113): A form of non-syndromic, sensorineural deafness characterized by postlingual progressive hearing impairment. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Mansour, A., Sellon, J. B., Filizzola, D., Ghaffari, R., Cheatham, M. A., & Freeman, D. M. (2021). Age-related degradation of tectorial membrane dynamics with loss of CEACAM16. Biophysical Journal, 120(21), 4777-4785.

Dias, A. M. M., Lezirovitz, K., Nicastro, F. S., Mendes, B. C., & Mingroni-Netto, R. C. (2019). Further evidence for loss-of-function mutations in the CEACAM16 gene causing nonsyndromic autosomal recessive hearing loss in humans. Journal of human genetics, 64(3), 257-260.

Booth, K. T., Kahrizi, K., Najmabadi, H., Azaiez, H., & Smith, R. J. (2018). Old gene, new phenotype: splice-altering variants in CEACAM16 cause recessive non-syndromic hearing impairment. Journal of medical genetics, 55(8), 555-560.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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