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Mouse Anti-CEBPE Recombinant Antibody (CBFYC-1702) (CBMAB-C1764-FY)

This product is mouse antibody that recognizes CEBPE. The antibody CBFYC-1702 can be used for immunoassay techniques such as: Dot, WB.
See all CEBPE antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1702
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA
Preservative
0.05% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CEBPE
Introduction
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
Entrez Gene ID
UniProt ID
Alternative Names
CCAAT/Enhancer Binding Protein Epsilon; CCAAT/Enhancer Binding Protein (C/EBP), Epsilon; C/EBP Epsilon; CCAAT/Enhancer-Binding Protein Epsilon; C/EBP-Epsilon; CRP1
Function
Transcriptional activator (PubMed:26019275).
C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588).
Biological Process
Cellular response to lipopolysaccharide Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: Ensembl
Granulocyte differentiation Source: UniProtKB
Macrophage differentiation Source: Ensembl
Myeloid cell differentiation Source: GO_Central
Phagocytosis Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Specific granule deficiency 1 (SGD1): An autosomal recessive disorder characterized by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lack of neutrophil secondary granule proteins. Neutrophils of affected individuals lack lactoferrin and show abnormal nuclear segmentation, bilobed nuclei, low alkaline phosphatase, and increased number of neutrophil mitochondria and ribosomes.
PTM
Phosphorylated.

Stankiewicz, M. J., Du, J., Martinico, D., & Ackerman, S. J. (2021). CCAAT/Enhancer-Binding Protein ε27 Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding. International Journal of Molecular Sciences, 22(23), 12689.

Göös, H., Fogarty, C. L., Sahu, B., Plagnol, V., Rajamäki, K., Nurmi, K., ... & Seppänen, M. R. (2019). Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. Journal of Allergy and Clinical Immunology, 144(5), 1364-1376.

Shyamsunder, P., Shanmugasundaram, M., Mayakonda, A., Dakle, P., Teoh, W. W., Han, L., ... & Koeffler, H. P. (2019). Identification of a novel enhancer of CEBPE essential for granulocytic differentiation. Blood, The Journal of the American Society of Hematology, 133(23), 2507-2517.

Studd, J. B., Yang, M., Li, Z., Vijayakrishnan, J., Lu, Y., Yeoh, A. E. J., ... & Houlston, R. S. (2019). Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11. 2 is mediated by a CEBPE promoter polymorphism. Leukemia, 33(1), 1-14.

Serwas, N. K., Huemer, J., Dieckmann, R., Mejstrikova, E., Garncarz, W., Litzman, J., ... & Boztug, K. (2018). CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils. Frontiers in immunology, 9, 588.

Burmeister, T. (2017). CEBPE (CCAAT/enhancer binding protein epsilon). Atlas of Genetics and Cytogenetics in Oncology and Haematology.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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