Mouse Anti-CENPM Recombinant Antibody (4C12-2C8) (CBMAB-A0974-LY)

Name: Mouse Anti-CENPM Recombinant Antibody (4C12-2C8)
SKU: CBMAB-A0974-LY
Rating: 5 (1 reviews)

See all CENPM antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4C12-2C8

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

Full length recombinant CENPM.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Centromere Protein M

Introduction

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM

Entrez Gene ID

79019

UniProt ID

Q9NSP4

Alternative Names

C22orf18; CENP-M; MGC861; PANE1; bK250D10.2

Function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Biological Process

CENP-A containing nucleosome assembly Source: Reactome
Mitotic spindle organization Source: Reactome

Cellular Location

Nucleus; Cytoplasm; Kinetochore. Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres.

More Infomation

References

Mamoor, S. (2021). Centromere protein M is differentially expressed in lymph nodes metastasis in human breast cancer.

Wu, Z. H., & Yang, D. L. (2020). High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining. Cancer Cell International, 20(1), 1-10.

Liu, Y., Yu, W., Ren, P., & Zhang, T. (2020). Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans. Molecular medicine reports, 22(5), 3922-3934.

Zou, Y., Sun, Z., & Sun, S. (2020). LncRNA HCG18 contributes to the progression of hepatocellular carcinoma via miR-214-3p/CENPM axis. The Journal of Biochemistry, 168(5), 535-546.

Zheng, C., Zhang, T., Li, D., Huang, C., Tang, H., Ni, X. F., & Chen, B. (2020). Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer. Oncology Reports, 44(3), 1003-1012.

Xiao, Y., Najeeb, R. M., Ma, D., Yang, K., Zhong, Q., & Liu, Q. (2019). Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Kim, W. T., Seo, S. P., Byun, Y. J., Kang, H. W., Kim, Y. J., Lee, S. C., ... & Kim, W. J. (2018). The anticancer effects of garlic extracts on bladder cancer compared to cisplatin: A common mechanism of action via centromere protein M. The American journal of Chinese medicine, 46(03), 689-705.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-CENPM Recombinant Antibody (4C12-2C8)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CENPM Recombinant Antibody (CBXC-0370)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: