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Mouse Anti-CEP152 Recombinant Antibody (CBXC-2385) (CBMAB-C3764-CQ)

This product is a mouse antibody that recognizes CEP152. The antibody CBXC-2385 can be used for immunoassay techniques such as: WB.
See all CEP152 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2385
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human CEP152.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Centrosomal Protein 152
Introduction
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants.
Entrez Gene ID
22995
UniProt ID
O94986
Alternative Names
Centrosomal Protein 152; Centrosomal Protein 152kDa; Asterless; Microcephaly, Primary Autosomal Recessive 4; Centrosomal Protein Of 152 KDa; KIAA0912;
Function
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).
Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615).
Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597).
Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity).
Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
Biological Process
Centriole replication Source: UniProtKB
Centrosome duplication Source: UniProtKB
Ciliary basal body-plasma membrane docking Source: Reactome
De novo centriole assembly involved in multi-ciliated epithelial cell differentiation Source: UniProtKB
G2/M transition of mitotic cell cycle Source: Reactome
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Cellular Location
Centrosome; Centriole. Colocalizes with CDK5RAP2, WDR62 and CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (PubMed:21983783, PubMed:26297806). Localizes to the deuterosome (By similarity). Localizes to pericentriolar material (PCM) (PubMed:26337392).
Involvement in disease
Microcephaly 9, primary, autosomal recessive (MCPH9): A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Seckel syndrome 5 (SCKL5): A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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