Mouse Anti-CEP152 Recombinant Antibody (CBXC-2385) (CBMAB-C3764-CQ)

Name: Mouse Anti-CEP152 Recombinant Antibody (CBXC-2385)
SKU: CBMAB-C3764-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-2385

Application

Immunogen

N-terminus region of human CEP152.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Centrosomal Protein 152

Introduction

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants.

Entrez Gene ID

22995

UniProt ID

O94986

Alternative Names

Centrosomal Protein 152; Centrosomal Protein 152kDa; Asterless; Microcephaly, Primary Autosomal Recessive 4; Centrosomal Protein Of 152 KDa; KIAA0912;

Function

Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).
Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615).
Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597).
Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity).
Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).

Biological Process

Centriole replication Source: UniProtKB
Centrosome duplication Source: UniProtKB
Ciliary basal body-plasma membrane docking Source: Reactome
De novo centriole assembly involved in multi-ciliated epithelial cell differentiation Source: UniProtKB
G2/M transition of mitotic cell cycle Source: Reactome
Regulation of G2/M transition of mitotic cell cycle Source: Reactome

Cellular Location

Centrosome; Centriole. Colocalizes with CDK5RAP2, WDR62 and CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (PubMed:21983783, PubMed:26297806). Localizes to the deuterosome (By similarity). Localizes to pericentriolar material (PCM) (PubMed:26337392).

Involvement in disease

Microcephaly 9, primary, autosomal recessive (MCPH9): A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Seckel syndrome 5 (SCKL5): A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.

Mahjabeen, I., Maqsood, Y., Abbasi, R., Ahmed, M. W., & Kayani, M. A. (2021). Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma. Future Oncology, (0).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-CEP152 Recombinant Antibody (EG646) (CAT#: CBMAB-EN779-LY)

Mouse Anti-CEP152 Recombinant Antibody (CBFYC-1723) (CAT#: CBMAB-C1785-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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